Synthesis process of KX2-361-D4 benzene sulfonate

Synthesis process of KX2-361-D4 benzene sulfonate

The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis process of KX2-361-D4 benzene sulfonate. The invention relates to a synthesis process of KX2-361-D4 benzene sulfonate, which comprises the following steps: by taking a compound I 1, 4-dibromob...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LI GUOFENG, CUI TANGWU, WANG MINGQUAN, YANG WEIQIANG, JIA QI
Format: Patent
Sprache:chi ; eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator LI GUOFENG
CUI TANGWU
WANG MINGQUAN
YANG WEIQIANG
JIA QI
description The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis process of KX2-361-D4 benzene sulfonate. The invention relates to a synthesis process of KX2-361-D4 benzene sulfonate, which comprises the following steps: by taking a compound I 1, 4-dibromobenzene-D4 as a raw material, coupling with morpholine in the presence of Pd2 (dba) 3, BINAP and sodium tert-butoxide to obtain a deuterated intermediate 2, namely 4-(4-bromophenyl-2, 3, 5, 6-D4) morpholine; the preparation method comprises the following steps: preparing four deuterium-labeled KX2-361-D4 benzene sulfonate from four deuterium-labeled KX2-361-D4, sequentially carrying out Suzuki coupling, SNAr reaction, cyano hydrolysis reaction and amide condensation reaction to prepare KX2-361-D4, and finally salifying with benzenesulfonic acid to obtain the four deuterium-labeled KX2-361-D4 benzene sulfonate. The synthesis method of the KX2-361-D4 benzene sulfonate has the following technical effects that the synth
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN117865880A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN117865880A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN117865880A3</originalsourceid><addsrcrecordid>eNrjZDAMrswryUgtzixWKCjKT04tLlbIT1PwjjDSNTYz1HUxUUhKzatKzUtVKC7NScvPSyxJ5WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFiclA5SXxzn6GhuYWZqYWFgaOxsSoAQAB2ypn</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Synthesis process of KX2-361-D4 benzene sulfonate</title><source>esp@cenet</source><creator>LI GUOFENG ; CUI TANGWU ; WANG MINGQUAN ; YANG WEIQIANG ; JIA QI</creator><creatorcontrib>LI GUOFENG ; CUI TANGWU ; WANG MINGQUAN ; YANG WEIQIANG ; JIA QI</creatorcontrib><description>The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis process of KX2-361-D4 benzene sulfonate. The invention relates to a synthesis process of KX2-361-D4 benzene sulfonate, which comprises the following steps: by taking a compound I 1, 4-dibromobenzene-D4 as a raw material, coupling with morpholine in the presence of Pd2 (dba) 3, BINAP and sodium tert-butoxide to obtain a deuterated intermediate 2, namely 4-(4-bromophenyl-2, 3, 5, 6-D4) morpholine; the preparation method comprises the following steps: preparing four deuterium-labeled KX2-361-D4 benzene sulfonate from four deuterium-labeled KX2-361-D4, sequentially carrying out Suzuki coupling, SNAr reaction, cyano hydrolysis reaction and amide condensation reaction to prepare KX2-361-D4, and finally salifying with benzenesulfonic acid to obtain the four deuterium-labeled KX2-361-D4 benzene sulfonate. The synthesis method of the KX2-361-D4 benzene sulfonate has the following technical effects that the synth</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20240412&amp;DB=EPODOC&amp;CC=CN&amp;NR=117865880A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20240412&amp;DB=EPODOC&amp;CC=CN&amp;NR=117865880A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI GUOFENG</creatorcontrib><creatorcontrib>CUI TANGWU</creatorcontrib><creatorcontrib>WANG MINGQUAN</creatorcontrib><creatorcontrib>YANG WEIQIANG</creatorcontrib><creatorcontrib>JIA QI</creatorcontrib><title>Synthesis process of KX2-361-D4 benzene sulfonate</title><description>The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis process of KX2-361-D4 benzene sulfonate. The invention relates to a synthesis process of KX2-361-D4 benzene sulfonate, which comprises the following steps: by taking a compound I 1, 4-dibromobenzene-D4 as a raw material, coupling with morpholine in the presence of Pd2 (dba) 3, BINAP and sodium tert-butoxide to obtain a deuterated intermediate 2, namely 4-(4-bromophenyl-2, 3, 5, 6-D4) morpholine; the preparation method comprises the following steps: preparing four deuterium-labeled KX2-361-D4 benzene sulfonate from four deuterium-labeled KX2-361-D4, sequentially carrying out Suzuki coupling, SNAr reaction, cyano hydrolysis reaction and amide condensation reaction to prepare KX2-361-D4, and finally salifying with benzenesulfonic acid to obtain the four deuterium-labeled KX2-361-D4 benzene sulfonate. The synthesis method of the KX2-361-D4 benzene sulfonate has the following technical effects that the synth</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAMrswryUgtzixWKCjKT04tLlbIT1PwjjDSNTYz1HUxUUhKzatKzUtVKC7NScvPSyxJ5WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFiclA5SXxzn6GhuYWZqYWFgaOxsSoAQAB2ypn</recordid><startdate>20240412</startdate><enddate>20240412</enddate><creator>LI GUOFENG</creator><creator>CUI TANGWU</creator><creator>WANG MINGQUAN</creator><creator>YANG WEIQIANG</creator><creator>JIA QI</creator><scope>EVB</scope></search><sort><creationdate>20240412</creationdate><title>Synthesis process of KX2-361-D4 benzene sulfonate</title><author>LI GUOFENG ; CUI TANGWU ; WANG MINGQUAN ; YANG WEIQIANG ; JIA QI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117865880A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LI GUOFENG</creatorcontrib><creatorcontrib>CUI TANGWU</creatorcontrib><creatorcontrib>WANG MINGQUAN</creatorcontrib><creatorcontrib>YANG WEIQIANG</creatorcontrib><creatorcontrib>JIA QI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI GUOFENG</au><au>CUI TANGWU</au><au>WANG MINGQUAN</au><au>YANG WEIQIANG</au><au>JIA QI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Synthesis process of KX2-361-D4 benzene sulfonate</title><date>2024-04-12</date><risdate>2024</risdate><abstract>The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis process of KX2-361-D4 benzene sulfonate. The invention relates to a synthesis process of KX2-361-D4 benzene sulfonate, which comprises the following steps: by taking a compound I 1, 4-dibromobenzene-D4 as a raw material, coupling with morpholine in the presence of Pd2 (dba) 3, BINAP and sodium tert-butoxide to obtain a deuterated intermediate 2, namely 4-(4-bromophenyl-2, 3, 5, 6-D4) morpholine; the preparation method comprises the following steps: preparing four deuterium-labeled KX2-361-D4 benzene sulfonate from four deuterium-labeled KX2-361-D4, sequentially carrying out Suzuki coupling, SNAr reaction, cyano hydrolysis reaction and amide condensation reaction to prepare KX2-361-D4, and finally salifying with benzenesulfonic acid to obtain the four deuterium-labeled KX2-361-D4 benzene sulfonate. The synthesis method of the KX2-361-D4 benzene sulfonate has the following technical effects that the synth</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN117865880A
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Synthesis process of KX2-361-D4 benzene sulfonate
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T11%3A42%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LI%20GUOFENG&rft.date=2024-04-12&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN117865880A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true