Dimer impurity of cinacalcet key intermediate and preparation method thereof

The invention relates to a dimer impurity of a cinacalcet key intermediate and a preparation method of the dimer impurity, and belongs to the technical field of medicinal chemistry. The structure of the dimer impurity is # imgabs0 #. Impurities are one of key quality attributes of drugs and affect the safety and effectiveness of the drugs, the cinacalcet intermediate dimer impurities provided by the invention widen the variety of impurities generated in the cinacalcet preparation process, can be used as impurity reference substances of cinacalcet and intermediates thereof, and can be used for preparing the cinacalcet intermediate dimer impurities. The method has guiding significance for development and optimization of a cinacalcet preparation process and establishment of a drug quality control strategy. 本发明涉及一种西那卡塞关键中间体的二聚体杂质及其制备方法，属于药物化学技术领域。二聚体杂质的结构为#imgabs0#。杂质是药品的关键质量属性之一，影响药品的安全性和有效性，本发明提供的西那卡塞中间体二聚体杂质拓宽了西那卡塞制备过程产生杂质的种类，可以作为西那卡塞及其中间体的杂质对照品，对于西那卡塞制备工艺的开发和优化、药物质量控制策略的建立具有指导意义。