Design and application of temperature-sensitive peptidyl aggregate probe capable of realizing solid-liquid phase change

The invention discloses design and application of a temperature-sensitive type peptidyl aggregate probe capable of realizing solid-liquid phase change, and belongs to the technical field of biomedicine. The peptidyl probe can form condensed liquid drops through solid-liquid phase transformation at the temperature close to the body temperature, can form gel at the room temperature, and can penetrate through a cell membrane and be combined with RNA to generate fluorescence. 本发明公开了一种温敏型可固-液相变的肽基凝聚体探针的设计及其应用，属于生物医学技术领域。该肽基探针在体温附近时可通过固-液相变形成凝聚体液滴，并在室温形成凝胶，可穿越细胞膜并于RNA结合产生荧光。