Composition for simultaneously activating immune regulation and anti-oxidation pathway to relieve vaginitis
The invention discloses a composition for simultaneously activating immune regulation and an antioxidant pathway to relieve vaginitis, and belongs to the technical field of microorganisms. According to the invention, a composite strain containing a strain of Lactobacillus paracasei CCFM1316 and a st...
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| creator | CHEN WEI LIN RUMENG MAO BINGYONG ZHAO JIANXIN TANG XIN CUI SHUMAO ZHANG QIUXIANG |
| description | The invention discloses a composition for simultaneously activating immune regulation and an antioxidant pathway to relieve vaginitis, and belongs to the technical field of microorganisms. According to the invention, a composite strain containing a strain of Lactobacillus paracasei CCFM1316 and a strain of Lactobacillus paracasei CCFM1317 is obtained through screening, and the composition containing the composite strain has the effect of repairing related symptoms such as immune disorder and oxidative damage caused by vaginitis, which is specifically embodied as follows: regulating the vaginal immune response of mice: activating a TLR-4/MyD88 pathway, and activating the TLR-4/MyD88 pathway; the IL-1beta concentration of the vaginal tissue is reduced to 29.79 ng/L; the oxidative stress of the vagina of the mouse is improved; the Nrf2 of the vaginal tissue is increased to 36.58 ng/L; therefore, the composition of the lactobacillus paracasei CCFM1316 and the lactobacillus paracasei CCFM1317 has a huge applicatio |
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According to the invention, a composite strain containing a strain of Lactobacillus paracasei CCFM1316 and a strain of Lactobacillus paracasei CCFM1317 is obtained through screening, and the composition containing the composite strain has the effect of repairing related symptoms such as immune disorder and oxidative damage caused by vaginitis, which is specifically embodied as follows: regulating the vaginal immune response of mice: activating a TLR-4/MyD88 pathway, and activating the TLR-4/MyD88 pathway; the IL-1beta concentration of the vaginal tissue is reduced to 29.79 ng/L; the oxidative stress of the vagina of the mouse is improved; the Nrf2 of the vaginal tissue is increased to 36.58 ng/L; therefore, the composition of the lactobacillus paracasei CCFM1316 and the lactobacillus paracasei CCFM1317 has a huge applicatio</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; ENZYMOLOGY ; FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240305&DB=EPODOC&CC=CN&NR=117645942A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25546,76297</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240305&DB=EPODOC&CC=CN&NR=117645942A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN WEI</creatorcontrib><creatorcontrib>LIN RUMENG</creatorcontrib><creatorcontrib>MAO BINGYONG</creatorcontrib><creatorcontrib>ZHAO JIANXIN</creatorcontrib><creatorcontrib>TANG XIN</creatorcontrib><creatorcontrib>CUI SHUMAO</creatorcontrib><creatorcontrib>ZHANG QIUXIANG</creatorcontrib><title>Composition for simultaneously activating immune regulation and anti-oxidation pathway to relieve vaginitis</title><description>The invention discloses a composition for simultaneously activating immune regulation and an antioxidant pathway to relieve vaginitis, and belongs to the technical field of microorganisms. 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LIN RUMENG ; MAO BINGYONG ; ZHAO JIANXIN ; TANG XIN ; CUI SHUMAO ; ZHANG QIUXIANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117645942A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>ENZYMOLOGY</topic><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN WEI</creatorcontrib><creatorcontrib>LIN RUMENG</creatorcontrib><creatorcontrib>MAO BINGYONG</creatorcontrib><creatorcontrib>ZHAO JIANXIN</creatorcontrib><creatorcontrib>TANG XIN</creatorcontrib><creatorcontrib>CUI SHUMAO</creatorcontrib><creatorcontrib>ZHANG QIUXIANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN WEI</au><au>LIN RUMENG</au><au>MAO BINGYONG</au><au>ZHAO JIANXIN</au><au>TANG XIN</au><au>CUI SHUMAO</au><au>ZHANG QIUXIANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Composition for simultaneously activating immune regulation and anti-oxidation pathway to relieve vaginitis</title><date>2024-03-05</date><risdate>2024</risdate><abstract>The invention discloses a composition for simultaneously activating immune regulation and an antioxidant pathway to relieve vaginitis, and belongs to the technical field of microorganisms. According to the invention, a composite strain containing a strain of Lactobacillus paracasei CCFM1316 and a strain of Lactobacillus paracasei CCFM1317 is obtained through screening, and the composition containing the composite strain has the effect of repairing related symptoms such as immune disorder and oxidative damage caused by vaginitis, which is specifically embodied as follows: regulating the vaginal immune response of mice: activating a TLR-4/MyD88 pathway, and activating the TLR-4/MyD88 pathway; the IL-1beta concentration of the vaginal tissue is reduced to 29.79 ng/L; the oxidative stress of the vagina of the mouse is improved; the Nrf2 of the vaginal tissue is increased to 36.58 ng/L; therefore, the composition of the lactobacillus paracasei CCFM1316 and the lactobacillus paracasei CCFM1317 has a huge applicatio</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE |
| title | Composition for simultaneously activating immune regulation and anti-oxidation pathway to relieve vaginitis |
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