Sheep milk casein enzymolysis polypeptide as well as composition, screening method and application thereof
The invention provides a sheep milk casein enzymolysis polypeptide as well as a composition, a screening method and application thereof, and the amino acid sequence of the polypeptide is KPW, as shown in SEQ ID NO: 93; and/or the amino acid sequence of the polypeptide is MPLW, as shown in SEQ ID NO:...
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| creator | PAN LINA GAO YU WANG SHANSHAN PENG XIAOYU WANG JIAQI LI WEI XIE YU GUO DANYING |
| description | The invention provides a sheep milk casein enzymolysis polypeptide as well as a composition, a screening method and application thereof, and the amino acid sequence of the polypeptide is KPW, as shown in SEQ ID NO: 93; and/or the amino acid sequence of the polypeptide is MPLW, as shown in SEQ ID NO: 66. The half inhibitory concentration IC50 value of the polypeptide KPW is 1.86 +/-0.08 mg/mL, the half inhibitory concentration IC50 value of the polypeptide MPLW is 1.51 +/-0.06 mg/mL, and the two peptides have an inhibition effect on xanthine oxidase and have uric acid reduction activity.
本发明提供羊乳酪蛋白酶解多肽及其组合物、筛选方法和用途，所述多肽的氨基酸序列为KPW，如SEQ ID NO:93所示；和/或所述多肽的氨基酸序列为MPLW，如SEQ ID NO:66所示。本发明中多肽KPW的半抑制浓度IC50值为1.86±0.08mg/mL，多肽MPLW的半抑制浓度IC50值为1.51±0.06mg/mL，两个肽对黄嘌呤氧化酶具有抑制的效果，具有降尿酸活性。 |
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本发明提供羊乳酪蛋白酶解多肽及其组合物、筛选方法和用途，所述多肽的氨基酸序列为KPW，如SEQ ID NO:93所示；和/或所述多肽的氨基酸序列为MPLW，如SEQ ID NO:66所示。本发明中多肽KPW的半抑制浓度IC50值为1.86±0.08mg/mL，多肽MPLW的半抑制浓度IC50值为1.51±0.06mg/mL，两个肽对黄嘌呤氧化酶具有抑制的效果，具有降尿酸活性。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HUMAN NECESSITIES ; HYGIENE ; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240301&DB=EPODOC&CC=CN&NR=117624290A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240301&DB=EPODOC&CC=CN&NR=117624290A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PAN LINA</creatorcontrib><creatorcontrib>GAO YU</creatorcontrib><creatorcontrib>WANG SHANSHAN</creatorcontrib><creatorcontrib>PENG XIAOYU</creatorcontrib><creatorcontrib>WANG JIAQI</creatorcontrib><creatorcontrib>LI WEI</creatorcontrib><creatorcontrib>XIE YU</creatorcontrib><creatorcontrib>GUO DANYING</creatorcontrib><title>Sheep milk casein enzymolysis polypeptide as well as composition, screening method and application thereof</title><description>The invention provides a sheep milk casein enzymolysis polypeptide as well as a composition, a screening method and application thereof, and the amino acid sequence of the polypeptide is KPW, as shown in SEQ ID NO: 93; and/or the amino acid sequence of the polypeptide is MPLW, as shown in SEQ ID NO: 66. The half inhibitory concentration IC50 value of the polypeptide KPW is 1.86 +/-0.08 mg/mL, the half inhibitory concentration IC50 value of the polypeptide MPLW is 1.51 +/-0.06 mg/mL, and the two peptides have an inhibition effect on xanthine oxidase and have uric acid reduction activity.
本发明提供羊乳酪蛋白酶解多肽及其组合物、筛选方法和用途，所述多肽的氨基酸序列为KPW，如SEQ ID NO:93所示；和/或所述多肽的氨基酸序列为MPLW，如SEQ ID NO:66所示。本发明中多肽KPW的半抑制浓度IC50值为1.86±0.08mg/mL，多肽MPLW的半抑制浓度IC50值为1.51±0.06mg/mL，两个肽对黄嘌呤氧化酶具有抑制的效果，具有降尿酸活性。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrsKwkAQRuE0FqK-w9grGBXFUoJiZaN9WDZ_zOhehsyCxKc3AR_A4vA1Z5w9bw0g5Nm9yBoFB0L4dD66TllJegWSuAIZpTecG7TRS1ROHMOC1LZA4PAgj9TEikzoE3FszXBQatAi1tNsVBunmP2cZPPz6V5clpBYQsVYBKSyuOb5frferg-r4-af5wvvIUG6</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>PAN LINA</creator><creator>GAO YU</creator><creator>WANG SHANSHAN</creator><creator>PENG XIAOYU</creator><creator>WANG JIAQI</creator><creator>LI WEI</creator><creator>XIE YU</creator><creator>GUO DANYING</creator><scope>EVB</scope></search><sort><creationdate>20240301</creationdate><title>Sheep milk casein enzymolysis polypeptide as well as composition, screening method and application thereof</title><author>PAN LINA ; GAO YU ; WANG SHANSHAN ; PENG XIAOYU ; WANG JIAQI ; LI WEI ; XIE YU ; GUO DANYING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117624290A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>PAN LINA</creatorcontrib><creatorcontrib>GAO YU</creatorcontrib><creatorcontrib>WANG SHANSHAN</creatorcontrib><creatorcontrib>PENG XIAOYU</creatorcontrib><creatorcontrib>WANG JIAQI</creatorcontrib><creatorcontrib>LI WEI</creatorcontrib><creatorcontrib>XIE YU</creatorcontrib><creatorcontrib>GUO DANYING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PAN LINA</au><au>GAO YU</au><au>WANG SHANSHAN</au><au>PENG XIAOYU</au><au>WANG JIAQI</au><au>LI WEI</au><au>XIE YU</au><au>GUO DANYING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Sheep milk casein enzymolysis polypeptide as well as composition, screening method and application thereof</title><date>2024-03-01</date><risdate>2024</risdate><abstract>The invention provides a sheep milk casein enzymolysis polypeptide as well as a composition, a screening method and application thereof, and the amino acid sequence of the polypeptide is KPW, as shown in SEQ ID NO: 93; and/or the amino acid sequence of the polypeptide is MPLW, as shown in SEQ ID NO: 66. The half inhibitory concentration IC50 value of the polypeptide KPW is 1.86 +/-0.08 mg/mL, the half inhibitory concentration IC50 value of the polypeptide MPLW is 1.51 +/-0.06 mg/mL, and the two peptides have an inhibition effect on xanthine oxidase and have uric acid reduction activity.
本发明提供羊乳酪蛋白酶解多肽及其组合物、筛选方法和用途，所述多肽的氨基酸序列为KPW，如SEQ ID NO:93所示；和/或所述多肽的氨基酸序列为MPLW，如SEQ ID NO:66所示。本发明中多肽KPW的半抑制浓度IC50值为1.86±0.08mg/mL，多肽MPLW的半抑制浓度IC50值为1.51±0.06mg/mL，两个肽对黄嘌呤氧化酶具有抑制的效果，具有降尿酸活性。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE |
| title | Sheep milk casein enzymolysis polypeptide as well as composition, screening method and application thereof |
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