Glucose sensitive albumin binding derivatives

The present invention relates to glucose sensitive albumin binding diboron conjugates. More specifically, the present invention provides novel diboron compounds useful as intermediate compounds for the synthesis of diboron conjugates, in particular diboronic acid or diboronic oxalane compounds. The diboron compounds are characterized by formula (I): R1-X-R2 wherein "X" is a monatomic to polyatomic linker, and wherein R1 and R2, which may be the same or different, each represent a group of formula (IIa) or (IIb). Also described are diboron conjugates represented by the general formula (I '): R1'-X '-R2' wherein a portion of R1 'or R2' or X 'carries a drug covalently attached to the diboron compound. # imgabs0 # 本发明涉及葡萄糖敏感性白蛋白结合二硼缀合物。更具体地，本发明提供了可作为中间体化合物用于合成二硼缀合物的新型二硼化合物，特别是二硼酸或双硼氧杂戊环化合物。所述二硼化合物的特征在于式(I)，其为：R1-X-R2，其中"X"为单原子至多原子连接体，并且其中R1和R2可以相同或不同，各自代表式(IIa)或(IIb)的基团。还描述了由通式(I')代表的二硼缀合物，其为：R1'-X'-R2'，其中部分R1'或R2'或X'带有与该二硼化合物共价连接的药物。#imgabs0#