Synthesis method of spiroxamine

The invention relates to the field of chemical synthesis, in particular to a spiroxamine synthesis method which comprises the following steps: synthesizing 8-(tert-butyl)-2-(hydroxymethyl)-1, 4-dioxaspiro [4.5] decane by taking glycerol and p-tert-butyl cyclohexanone as raw materials, brominating the reaction liquid in the step 1) without treatment to obtain 8-(tert-butyl)-2-(bromomethyl)-1, 4-dioxaspiro [4.5] decane, and then adding the 8-(tert-butyl)-2-(bromomethyl)-1, 4-dioxaspiro [4.5] decane into the reaction liquid in the step 2) to obtain 8-(tert-butyl)-2-(bromomethyl)-1, 4-dioxaspiro [4.5] decane. And finally, aminating to obtain the product spiroxamine. The synthesis method of spiroxamine provided by the invention has the advantages of short route, mild reaction conditions, realization of the reflux reaction in a common enamel kettle in the final amination reaction, no side reaction, simple post-treatment, high product purity, high yield, facilitation of the industrial production of spiroxamine, and