Preparation method of 2-(6-(benzyloxy)-3, 4-dihydronaphthalene-2-yl)-4, 4, 5-5-tetramethyl-1, 3, 2-dioxaborane

Preparation method of 2-(6-(benzyloxy)-3, 4-dihydronaphthalene-2-yl)-4, 4, 5-5-tetramethyl-1, 3, 2-dioxaborane

The invention is applicable to the technical field of drug synthesis, and provides a preparation method of 2-(6-(benzyloxy)-3, 4-dihydronaphthalene-2-yl)-4, 4, 5-5-tetramethyl-1, 3, 2-dioxaborane, which comprises the following steps: carrying out substitution reaction on 6-hydroxyl-3, 4-dihydro-1H-2...

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Hauptverfasser: CUI DEXIU, LIU WEIWEN, LIU HUA, KOU HANG
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Sprache:chi ; eng
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator CUI DEXIU
LIU WEIWEN
LIU HUA
KOU HANG
description The invention is applicable to the technical field of drug synthesis, and provides a preparation method of 2-(6-(benzyloxy)-3, 4-dihydronaphthalene-2-yl)-4, 4, 5-5-tetramethyl-1, 3, 2-dioxaborane, which comprises the following steps: carrying out substitution reaction on 6-hydroxyl-3, 4-dihydro-1H-2-naphthalenone in an organic solvent, carbonate, potassium iodide and a benzyl halogenated hydrocarbon system to obtain 2-(6-(benzyloxy)-3, 4-dihydronaphthalene-2-yl)-4, 4, 5-tetramethyl-1, 3, 2-dioxaborane. The preparation method comprises the following steps: reacting an obtained compound in a lithium diisopropylamide and tetrahydrofuran system, then adding bis (trifluoromethanesulfonic acid) imine for reaction, and carrying out coupling reaction on the obtained compound and bis (pinacolato) diboron in a potassium acetate, bis (triphenylphosphine) palladium dichloride and ethylene glycol dimethyl ether system. According to the present invention, the 6-hydroxy-3, 4-dihydro-1H-2-naphthalenone is adopted as the star
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The preparation method comprises the following steps: reacting an obtained compound in a lithium diisopropylamide and tetrahydrofuran system, then adding bis (trifluoromethanesulfonic acid) imine for reaction, and carrying out coupling reaction on the obtained compound and bis (pinacolato) diboron in a potassium acetate, bis (triphenylphosphine) palladium dichloride and ethylene glycol dimethyl ether system. 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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Preparation method of 2-(6-(benzyloxy)-3, 4-dihydronaphthalene-2-yl)-4, 4, 5-5-tetramethyl-1, 3, 2-dioxaborane
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