Application of C21 steroid deoxidized oligoglycoside compounds in preparation of anticomplement drugs
The invention belongs to the field of traditional Chinese medicine preparation, and relates to a C21 steroid deoxy oligoglycoside compound and application thereof in preparation of anticomplement drugs. According to the invention, three C21 steroid deoxidized oligoglycoside compounds, namely, cynanc...
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Zusammenfassung: | The invention belongs to the field of traditional Chinese medicine preparation, and relates to a C21 steroid deoxy oligoglycoside compound and application thereof in preparation of anticomplement drugs. According to the invention, three C21 steroid deoxidized oligoglycoside compounds, namely, cynanchum sibiricum elements A-C, are separated from an n-butyl alcohol extraction part of a 95% ethanol extract of dried roots of metaplexaceae plant cynanchum sibiricum, and an in-vitro anti-complement activity evaluation experiment proves that the cynanchum sibiricum elements A-C have a relatively strong inhibition effect on both a classical pathway and an alternative pathway of a complement system. The C21 steroid deoxidized oligoglycoside compound disclosed by the invention can be used for preparing an anti-complement medicine and further preparing a medicine for treating complement-related diseases.
本发明属于中药制药领域,涉及C21甾体脱氧寡糖苷类化合物及其在制备抗补体药物中的用途。本发明从萝藦科植物戟叶鹅绒藤(Cynanchum sibiricum Willd.)干燥根95%乙醇提取物的正丁醇萃取部位中分离得到3个C21甾体脱 |
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