Three-color probe composition, kit and application in diagnosis of long arm deletion of chromosome 20

The invention specifically discloses a three-color probe composition, a kit and application in long-arm deletion diagnosis of chromosome 20, the three-color probe composition detects 20p11/20q12/20q13 based on the FISH technology, the probe group can judge tumors of different delta (20q) subtypes ac...

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Hauptverfasser:	YANG JIANMIN, CHEN GANG, TANG GUSHENG, ZHANG YAN, GUO MENGQIAO, CAO HAOFEI, GUO FANGYU, LI XUEMEI, WU XIAN, GONG SHENGLAN, LI QIAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention specifically discloses a three-color probe composition, a kit and application in long-arm deletion diagnosis of chromosome 20, the three-color probe composition detects 20p11/20q12/20q13 based on the FISH technology, the probe group can judge tumors of different delta (20q) subtypes according to different signal results, the accuracy rate is high, the specificity is high, the success rate is high, the fluorescence signal is strong, and the detection sensitivity is high. The operation is simple and rapid, rapid diagnosis can be realized, and a novel method for accurately and reliably detecting the delta (20q) hematologic tumor is established. 本发明具体公开了一种三色探针组合物、试剂盒及在20号染色体长臂缺失诊断中的应用，所述三色探针组合物基于FISH技术检测20p11/20q12/20q13，所述探针组能够根据不同的信号结果判断出不同del(20q)亚型的肿瘤，准确率高、特异性高、成功率高，荧光信号强，操作简单快捷，可快速诊断，建立了准确可靠地检测del(20q)血液肿瘤的新方法。