Capecitabine solid dispersible tablet and preparation method thereof

Capecitabine solid dispersible tablet and preparation method thereof

The invention belongs to the technical field of medicines, and particularly relates to capecitabine solid dispersible tablets and a preparation method thereof. The preparation method of the capecitabine solid dispersible tablet comprises the following steps: dissolving 250 parts of capecitabine and...

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Hauptverfasser: SUN SHENGHUA, GUAN YUEQIN, WANG XIULAN
Format: Patent
Sprache:chi ; eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator SUN SHENGHUA
GUAN YUEQIN
WANG XIULAN
description The invention belongs to the technical field of medicines, and particularly relates to capecitabine solid dispersible tablets and a preparation method thereof. The preparation method of the capecitabine solid dispersible tablet comprises the following steps: dissolving 250 parts of capecitabine and 125-625 parts of a water-soluble dispersion carrier in an alcoholic solution to prepare a mixed solution; carrying out spray drying on the mixed solution; mixing the capecitabine solid dispersible powder with 29-620 parts of a diluent, 1-5 parts of an adhesive, 3-10 parts of a lubricant, 20-80 parts of a disintegrating agent, 1-5 parts of a flow aid and 2-5 parts of a flavoring agent, granulating, and tabletting to obtain the capecitabine solid dispersible tablet. The solid dispersion prepared by using the water-soluble substance as the dispersion carrier not only maintains the highly dispersed state of the capecitabine drug, but also has good wettability to the capecitabine drug, improves the solubility of the dru
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Capecitabine solid dispersible tablet and preparation method thereof
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