Recombinant interferon drug targeting conservative HIV gp41 subunit membrane-proximal ectodomain and application thereof
The invention discloses a recombinant interferon drug targeting a conservative HIV (human immunodeficiency virus) gp41 subunit membrane-proximal ectodomain and application of the recombinant interferon drug. Comprising a 10E8 antibody or an antigen binding fragment thereof and a consensus interferon...
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| creator | JIAO CHANGLE HU JIAQI YUAN SHENGLING DAI JINGJING GUAN TONGTONG HU XIANWEN WEI YUANYUAN ZUO MENG LIU ZILONG YUAN JIANJUN ZHANG LIFANG LIAO XIANG LI LEI |
| description | The invention discloses a recombinant interferon drug targeting a conservative HIV (human immunodeficiency virus) gp41 subunit membrane-proximal ectodomain and application of the recombinant interferon drug. Comprising a 10E8 antibody or an antigen binding fragment thereof and a consensus interferon alpha, and the 10E8 antibody or the antigen binding fragment thereof is connected with the consensus interferon alpha through a linker. The antibody 10E8 capable of recognizing a highly conservative gp41 subunit MPER region of HIV outer membrane glycoprotein is used as a directional tool of the integrated interferon, a target spot exposed by an outer membrane protein allosteric structure of a virus in an infected cell can be accurately recognized, virus infection is prevented, a neutralization effect is achieved, and meanwhile, the antibody 10E8 can be used for identifying the high conservative gp41 subunit MPER region of the HIV outer membrane glycoprotein. The carried interferon molecules can be more effectively |
| format | Patent |
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Comprising a 10E8 antibody or an antigen binding fragment thereof and a consensus interferon alpha, and the 10E8 antibody or the antigen binding fragment thereof is connected with the consensus interferon alpha through a linker. The antibody 10E8 capable of recognizing a highly conservative gp41 subunit MPER region of HIV outer membrane glycoprotein is used as a directional tool of the integrated interferon, a target spot exposed by an outer membrane protein allosteric structure of a virus in an infected cell can be accurately recognized, virus infection is prevented, a neutralization effect is achieved, and meanwhile, the antibody 10E8 can be used for identifying the high conservative gp41 subunit MPER region of the HIV outer membrane glycoprotein. 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Comprising a 10E8 antibody or an antigen binding fragment thereof and a consensus interferon alpha, and the 10E8 antibody or the antigen binding fragment thereof is connected with the consensus interferon alpha through a linker. The antibody 10E8 capable of recognizing a highly conservative gp41 subunit MPER region of HIV outer membrane glycoprotein is used as a directional tool of the integrated interferon, a target spot exposed by an outer membrane protein allosteric structure of a virus in an infected cell can be accurately recognized, virus infection is prevented, a neutralization effect is achieved, and meanwhile, the antibody 10E8 can be used for identifying the high conservative gp41 subunit MPER region of the HIV outer membrane glycoprotein. The carried interferon molecules can be more effectively</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | Recombinant interferon drug targeting conservative HIV gp41 subunit membrane-proximal ectodomain and application thereof |
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