Triazolo-pyrimidine analogs for treatment of diseases associated with wia syndrome RECQ helicase (WRN) inhibition

Triazolo-pyrimidine analogs for treatment of diseases associated with wia syndrome RECQ helicase (WRN) inhibition

The present invention provides compounds having formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, or pharmaceutically acceptable salts thereof, therapeutic uses of the compounds, uses of the compounds as research type chemicals, pharmaceut...

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Hauptverfasser: FUREGATTI, MAURIZIO, GOGNIAT GUILLAUME, PLATTNER, STEFAN, ZECRI FREDERIC, BORDAS VINCENT, HOLZER PHILIPP, HARMON, JOHN, MOEBITZ, HENRIK, DECKER ANDREAS, LIMAM, FATMA, HINRICHS JUERGEN HANS-HERMANN, SCHOEPFER JOSEPH, SOTO JULIO, YAO SHUPING, YU HUANGCHAO, GONG WANBEN, ZHANG SISI, SCHMIEDEBERG NIKO, BULLEN JULIE, NOCITO, STEFANO, STRONG ROLAND
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention provides compounds having formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, or pharmaceutically acceptable salts thereof, therapeutic uses of the compounds, uses of the compounds as research type chemicals, pharmaceutical compositions and combinations comprising the compounds, and processes for making compounds of the invention. # imgabs0 # 本发明提供了具有式(I)的化合物或其药学上可接受的盐：其中R1、R2、R3、R4、R5、R26、R27、y、R、M、W、L、V、T、Y、J、K和A如本文所述，还提供了所述化合物的治疗用途、所述化合物作为研究型化学物质的用途、包含所述化合物的药物组合物和组合、以及用于制造本发明的化合物的方法。#imgabs0#