Preparation method of isonicotinic acid derivative

Preparation method of isonicotinic acid derivative

The invention provides a preparation method of an isonicotinic acid derivative, which comprises the following steps: (1) reacting a compound as shown in a formula I with di-tert-butyl dicarbonate ester in a solvent in the presence of lithium diisopropylamide to obtain a compound as shown in a formul...

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Hauptverfasser: LUO GUIYUN, XUAN RUNHE, CAO YUN, ZHANG QING, ZHANG HUA, CHENG DEHAO, XIE YINGBO
Format: Patent
Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator LUO GUIYUN
XUAN RUNHE
CAO YUN
ZHANG QING
ZHANG HUA
CHENG DEHAO
XIE YINGBO
description The invention provides a preparation method of an isonicotinic acid derivative, which comprises the following steps: (1) reacting a compound as shown in a formula I with di-tert-butyl dicarbonate ester in a solvent in the presence of lithium diisopropylamide to obtain a compound as shown in a formula II; (2) reacting the compound as shown in the formula II with trifluoroacetic acid and triethyl silane in a solvent to obtain a compound as shown in a formula III, namely the isonicotinic acid derivative; compared with a traditional mode of directly introducing carbon dioxide and directly adding dry ice, the method for synthesizing the isonicotinic acid derivative provided by the invention has the advantages that almost no by-product is generated, and the method is simple to operate and treat, relatively low in experimental condition requirement, relatively low in reagent raw material cost, green and environment-friendly, and is suitable for industrial production. The concept of modern organic chemistry developme
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Preparation method of isonicotinic acid derivative
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