Bisoprolol amlodipine composition and preparation method thereof
The invention discloses a bisoprolol amlodipine composition and a preparation method thereof. Two active bisoprolol and amlodipine are respectively prepared into specific pellets, the pellets and auxiliary materials are mixed and tableted to obtain tablets, or the pellets and the auxiliary materials...
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| creator | ZHUGE MING CHEN LONG YU WENJIE TUO HAO ZHONG QICHANG DING YAFANG ZHANG QIAOYUN |
| description | The invention discloses a bisoprolol amlodipine composition and a preparation method thereof. Two active bisoprolol and amlodipine are respectively prepared into specific pellets, the pellets and auxiliary materials are mixed and tableted to obtain tablets, or the pellets and the auxiliary materials are homogenized and then filled into capsules, bisoprolol coatings are arranged on medicine layers on the surfaces of the pellets, and isolating layers are further arranged, so that bisoprolol and amlodipine are completely isolated, and the aim of improving the bioavailability of bisoprolol and amlodipine is fulfilled. Therefore, mutual contact of active ingredients and generation of impurities are avoided, and the impurity IMP-57 can be effectively controlled to be 0.1% or below. In addition, the bisoprolol pellets in the composition are subjected to medicine application and isolation treatment, and a formed isolation layer can bear pressure during tablet preparation and cannot generate cracks or cracks.
本发明公开比索洛 |
| format | Patent |
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本发明公开比索洛</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBwyizOLyjKz8nPUUjMzclPySzIzEtVSM7PLcgvzizJzM9TSMxLUSgoSi1ILEoE83NTSzLyUxRKMlKLUvPTeBhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoaG5sZGxsbGhozExagA2RjIY</recordid><startdate>20240102</startdate><enddate>20240102</enddate><creator>ZHUGE MING</creator><creator>CHEN LONG</creator><creator>YU WENJIE</creator><creator>TUO HAO</creator><creator>ZHONG QICHANG</creator><creator>DING YAFANG</creator><creator>ZHANG QIAOYUN</creator><scope>EVB</scope></search><sort><creationdate>20240102</creationdate><title>Bisoprolol amlodipine composition and preparation method thereof</title><author>ZHUGE MING ; CHEN LONG ; YU WENJIE ; TUO HAO ; ZHONG QICHANG ; DING YAFANG ; ZHANG QIAOYUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117323331A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHUGE MING</creatorcontrib><creatorcontrib>CHEN LONG</creatorcontrib><creatorcontrib>YU WENJIE</creatorcontrib><creatorcontrib>TUO HAO</creatorcontrib><creatorcontrib>ZHONG QICHANG</creatorcontrib><creatorcontrib>DING YAFANG</creatorcontrib><creatorcontrib>ZHANG QIAOYUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHUGE MING</au><au>CHEN LONG</au><au>YU WENJIE</au><au>TUO HAO</au><au>ZHONG QICHANG</au><au>DING YAFANG</au><au>ZHANG QIAOYUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Bisoprolol amlodipine composition and preparation method thereof</title><date>2024-01-02</date><risdate>2024</risdate><abstract>The invention discloses a bisoprolol amlodipine composition and a preparation method thereof. Two active bisoprolol and amlodipine are respectively prepared into specific pellets, the pellets and auxiliary materials are mixed and tableted to obtain tablets, or the pellets and the auxiliary materials are homogenized and then filled into capsules, bisoprolol coatings are arranged on medicine layers on the surfaces of the pellets, and isolating layers are further arranged, so that bisoprolol and amlodipine are completely isolated, and the aim of improving the bioavailability of bisoprolol and amlodipine is fulfilled. Therefore, mutual contact of active ingredients and generation of impurities are avoided, and the impurity IMP-57 can be effectively controlled to be 0.1% or below. In addition, the bisoprolol pellets in the composition are subjected to medicine application and isolation treatment, and a formed isolation layer can bear pressure during tablet preparation and cannot generate cracks or cracks.
本发明公开比索洛</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Bisoprolol amlodipine composition and preparation method thereof |
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