Oil gel patch and production process thereof

The invention discloses an oleogel patch and a production process thereof, an oily solvent is used as a main dispersion medium, a drug is dispersed in the oily solvent or a mixed solvent composed of the oily solvent, ethanol, a surfactant, glycerol and a small amount of water, then the drug is dispe...

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Bibliographische Detailangaben
Hauptverfasser: LEI JUFANG, WANG WEIBO, CHEN WEIWU
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses an oleogel patch and a production process thereof, an oily solvent is used as a main dispersion medium, a drug is dispersed in the oily solvent or a mixed solvent composed of the oily solvent, ethanol, a surfactant, glycerol and a small amount of water, then the drug is dispersed in a lipophilic gel skeleton, and in the oleogel, the proportion of the dispersion solvent can reach up to 80%, and the drug is dispersed in the lipophilic gel skeleton. The oil gel can be formed without or by using an extremely small amount of an oily dispersing solvent for volatile oil drugs with weak polarity, which means that the drug loading capacity of the drugs can be close to 80%. 本发明公开一种油凝胶贴剂及其生产工艺,使用油性溶剂作为主要分散介质,药物分散于油性溶剂或油性溶剂与乙醇、表面活性剂、甘油及少量水组成的混合溶剂中,然后分散于亲油性凝胶骨架中,在油凝胶中,分散溶剂的比例可高达80%,对于挥发油类药物弱极性药物,不用或使用极少量的油性分散溶剂即可形成油凝胶,对此类药物意味着载药量可以达到接近80%。