Double-Fmoc-protected Tirzeptide main chain 39 peptide as well as synthesis method and application of double-Fmoc-protected Tirzeptide main chain 39 peptide

The invention belongs to the field of polypeptide synthesis, and relates to an Fmoc-protected Tirzeptide main chain peptide as well as a synthesis method and application of the Fmoc-protected Tirzeptide main chain peptide. According to the invention, an orthogonal protection strategy is used, Fmoc protection is carried out on a 16-bit lysine side chain and an alpha-amino site of 1-bit tyrosine through a solid-phase synthesis method, and a solid foundation is laid for subsequent synthesis and application of Tirzeptide and analogues thereof. 本发明属于多肽合成领域，涉及Fmoc保护的Tirzepatide主链肽和合成方法及应用。本发明使用正交保护策略，通过固相合成的方法在16位赖氨酸侧链和1位酪氨酸的α-氨基位点进行Fmoc保护，为后续Tirzepatide及其类似物的合成应用奠定了坚实的基础。