Jaundice hepatocyte model and construction method thereof
The invention discloses a jaundice hepatocyte model and a construction method thereof. Comprising the following step: culturing hepatocytes in a culture medium containing bilirubin. According to the construction method of the jaundice hepatocyte model, the modeling duration of the jaundice hepatocyt...
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| creator | LI TONG LI AOLE HE CHUNYU KUANG YING MA YANHAO CHEN WEICONG LIU YANG HE SONGQI SUN HAITAO HU TIANTIAN YANG XUEMEI ZHONG BINGLIAN CHEN WEIGUANG |
| description | The invention discloses a jaundice hepatocyte model and a construction method thereof. Comprising the following step: culturing hepatocytes in a culture medium containing bilirubin. According to the construction method of the jaundice hepatocyte model, the modeling duration of the jaundice hepatocyte model can be effectively shortened, the construction cost is reduced, and the constructed jaundice hepatocyte model is longer in maintenance time and higher in stability, has a wide application prospect and is suitable for popularization and application. The jaundice hepatocyte model constructed by the invention can provide a test model basis for pharmacokinetic research, drug safety research and pharmacotoxicology research of jaundice.
本发明公开了一种黄疸肝细胞模型及其构建方法。包括以下步骤：将肝细胞置于含有胆红素的培养基中培养后即得。本发明的黄疸肝细胞模型构建方法能够有效缩短黄疸肝细胞模型的造模时长，降低构建成本，构建得到的黄疸肝细胞模型维持时间更久，稳定性更高，具有广泛的应用前景，本发明所构建的黄疸肝细胞模型可以为黄疸的药代动力学研究、药物安全性研究和药物毒理学研究提供试验模型基础。 |
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本发明公开了一种黄疸肝细胞模型及其构建方法。包括以下步骤：将肝细胞置于含有胆红素的培养基中培养后即得。本发明的黄疸肝细胞模型构建方法能够有效缩短黄疸肝细胞模型的造模时长，降低构建成本，构建得到的黄疸肝细胞模型维持时间更久，稳定性更高，具有广泛的应用前景，本发明所构建的黄疸肝细胞模型可以为黄疸的药代动力学研究、药物安全性研究和药物毒理学研究提供试验模型基础。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231114&DB=EPODOC&CC=CN&NR=117050930A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25573,76557</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231114&DB=EPODOC&CC=CN&NR=117050930A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI TONG</creatorcontrib><creatorcontrib>LI AOLE</creatorcontrib><creatorcontrib>HE CHUNYU</creatorcontrib><creatorcontrib>KUANG YING</creatorcontrib><creatorcontrib>MA YANHAO</creatorcontrib><creatorcontrib>CHEN WEICONG</creatorcontrib><creatorcontrib>LIU YANG</creatorcontrib><creatorcontrib>HE SONGQI</creatorcontrib><creatorcontrib>SUN HAITAO</creatorcontrib><creatorcontrib>HU TIANTIAN</creatorcontrib><creatorcontrib>YANG XUEMEI</creatorcontrib><creatorcontrib>ZHONG BINGLIAN</creatorcontrib><creatorcontrib>CHEN WEIGUANG</creatorcontrib><title>Jaundice hepatocyte model and construction method thereof</title><description>The invention discloses a jaundice hepatocyte model and a construction method thereof. Comprising the following step: culturing hepatocytes in a culture medium containing bilirubin. According to the construction method of the jaundice hepatocyte model, the modeling duration of the jaundice hepatocyte model can be effectively shortened, the construction cost is reduced, and the constructed jaundice hepatocyte model is longer in maintenance time and higher in stability, has a wide application prospect and is suitable for popularization and application. The jaundice hepatocyte model constructed by the invention can provide a test model basis for pharmacokinetic research, drug safety research and pharmacotoxicology research of jaundice.
本发明公开了一种黄疸肝细胞模型及其构建方法。包括以下步骤：将肝细胞置于含有胆红素的培养基中培养后即得。本发明的黄疸肝细胞模型构建方法能够有效缩短黄疸肝细胞模型的造模时长，降低构建成本，构建得到的黄疸肝细胞模型维持时间更久，稳定性更高，具有广泛的应用前景，本发明所构建的黄疸肝细胞模型可以为黄疸的药代动力学研究、药物安全性研究和药物毒理学研究提供试验模型基础。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD0SizNS8lMTlXISC1ILMlPrixJVcjNT0nNUUjMS1FIzs8rLikqTS7JzM9TyE0tychPUSjJSC1KzU_jYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhuYGpgaWxgaOxsSoAQBtIy8K</recordid><startdate>20231114</startdate><enddate>20231114</enddate><creator>LI TONG</creator><creator>LI AOLE</creator><creator>HE CHUNYU</creator><creator>KUANG YING</creator><creator>MA YANHAO</creator><creator>CHEN WEICONG</creator><creator>LIU YANG</creator><creator>HE SONGQI</creator><creator>SUN HAITAO</creator><creator>HU TIANTIAN</creator><creator>YANG XUEMEI</creator><creator>ZHONG BINGLIAN</creator><creator>CHEN WEIGUANG</creator><scope>EVB</scope></search><sort><creationdate>20231114</creationdate><title>Jaundice hepatocyte model and construction method thereof</title><author>LI TONG ; LI AOLE ; HE CHUNYU ; KUANG YING ; MA YANHAO ; CHEN WEICONG ; LIU YANG ; HE SONGQI ; SUN HAITAO ; HU TIANTIAN ; YANG XUEMEI ; ZHONG BINGLIAN ; CHEN WEIGUANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117050930A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LI TONG</creatorcontrib><creatorcontrib>LI AOLE</creatorcontrib><creatorcontrib>HE CHUNYU</creatorcontrib><creatorcontrib>KUANG YING</creatorcontrib><creatorcontrib>MA YANHAO</creatorcontrib><creatorcontrib>CHEN WEICONG</creatorcontrib><creatorcontrib>LIU YANG</creatorcontrib><creatorcontrib>HE SONGQI</creatorcontrib><creatorcontrib>SUN HAITAO</creatorcontrib><creatorcontrib>HU TIANTIAN</creatorcontrib><creatorcontrib>YANG XUEMEI</creatorcontrib><creatorcontrib>ZHONG BINGLIAN</creatorcontrib><creatorcontrib>CHEN WEIGUANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI TONG</au><au>LI AOLE</au><au>HE CHUNYU</au><au>KUANG YING</au><au>MA YANHAO</au><au>CHEN WEICONG</au><au>LIU YANG</au><au>HE SONGQI</au><au>SUN HAITAO</au><au>HU TIANTIAN</au><au>YANG XUEMEI</au><au>ZHONG BINGLIAN</au><au>CHEN WEIGUANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Jaundice hepatocyte model and construction method thereof</title><date>2023-11-14</date><risdate>2023</risdate><abstract>The invention discloses a jaundice hepatocyte model and a construction method thereof. Comprising the following step: culturing hepatocytes in a culture medium containing bilirubin. According to the construction method of the jaundice hepatocyte model, the modeling duration of the jaundice hepatocyte model can be effectively shortened, the construction cost is reduced, and the constructed jaundice hepatocyte model is longer in maintenance time and higher in stability, has a wide application prospect and is suitable for popularization and application. The jaundice hepatocyte model constructed by the invention can provide a test model basis for pharmacokinetic research, drug safety research and pharmacotoxicology research of jaundice.
本发明公开了一种黄疸肝细胞模型及其构建方法。包括以下步骤：将肝细胞置于含有胆红素的培养基中培养后即得。本发明的黄疸肝细胞模型构建方法能够有效缩短黄疸肝细胞模型的造模时长，降低构建成本，构建得到的黄疸肝细胞模型维持时间更久，稳定性更高，具有广泛的应用前景，本发明所构建的黄疸肝细胞模型可以为黄疸的药代动力学研究、药物安全性研究和药物毒理学研究提供试验模型基础。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Jaundice hepatocyte model and construction method thereof |
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