Diphenylphosphinyloxy-X-phenol compound, preparation method thereof and application of diphenylphosphinyloxy-X-phenol compound in preparation of aspartame

Diphenylphosphinyloxy-X-phenol compound, preparation method thereof and application of diphenylphosphinyloxy-X-phenol compound in preparation of aspartame

The invention relates to a diphenylphosphine acyloxy-X-phenol compound, a preparation method thereof and application of the diphenylphosphine acyloxy-X-phenol compound in preparation of aspartame, and belongs to the technical field of organic synthesis. The structural general formula of the diphenyl...

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Hauptverfasser: YANG LU, ZHAI MINZI, LIU SHUXIN, SHI MENGNAN, QIN CHUANGUANG
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Sprache:chi ; eng
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
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creator YANG LU
ZHAI MINZI
LIU SHUXIN
SHI MENGNAN
QIN CHUANGUANG
description The invention relates to a diphenylphosphine acyloxy-X-phenol compound, a preparation method thereof and application of the diphenylphosphine acyloxy-X-phenol compound in preparation of aspartame, and belongs to the technical field of organic synthesis. The structural general formula of the diphenylphosphine acyloxy-X-phenol compound DPXP is as shown in formula (I). The invention further provides a preparation method of the aspartame based on assistance of the diphenylphosphine acyloxy-X-phenol compound. According to the aspartame liquid-phase synthesis method assisted by the DPXP as the carrier, the auxiliary precipitation effect of the DPXP carrier is utilized, the preparation method of the aspartame is optimized and simplified through a strategy that liquid-phase reaction and equal-equivalent amino acid are coupled and Boc protection is removed, and the recoverability and reusability of the DPXP carrier are verified. 本发明涉及一种二苯基膦酰氧基-X-苯酚类化合物、制备方法及制备阿斯巴甜中的应用，属于有机合成技术领域。二苯基膦酰氧基-X-苯酚类化合物DPXP结构通式如式(Ⅰ)。本发明还提供了一种
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The structural general formula of the diphenylphosphine acyloxy-X-phenol compound DPXP is as shown in formula (I). The invention further provides a preparation method of the aspartame based on assistance of the diphenylphosphine acyloxy-X-phenol compound. 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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title Diphenylphosphinyloxy-X-phenol compound, preparation method thereof and application of diphenylphosphinyloxy-X-phenol compound in preparation of aspartame
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