Gene encoding chimeric receptor of anti-acetylcholine receptor autoantibody

The present invention provides a chimeric polypeptide receptor in which an extracellular region comprising an antigen region capable of being bound by an anti-human nicotine acetylcholine receptor alpha 1 subunit (nAChR alpha 1) antibody, a transmembrane region, and an intracellular domain comprising an intracellular signaling domain are arranged from the N-terminus to the C-terminus in the order of appearance, wherein the amino acid sequence of the antigen region comprises an amino acid sequence as shown in SEQ ID NO: 2 or an amino acid sequence derived from the amino acid sequence as shown in SEQ ID NO: 2 by substitution, deletion, insertion and/or addition of one or more amino acids, a polynucleotide encoding the chimeric polypeptide receptor polypeptide, a cell expressing the chimeric polypeptide receptor, and the like, the traditional Chinese medicine composition is used for treating myasthenia gravis. 本发明提供了嵌合多肽受体，其中包含能够被抗人烟碱性乙酰胆碱受体α1亚基(nAChRα1)抗体结合的抗原区域的细胞外区域、跨膜区域和包含细胞内信号传导结构域的细胞内结构域以出现的顺序从N-末端向C-末端排列，