DNA-crosslinked collagen material as well as preparation method and application thereof

The invention discloses a collagen material cross-linked with DNA (deoxyribonucleic acid) as well as a preparation method and application of the collagen material. DNA is crosslinked on the collagen material. The preparation method disclosed by the invention comprises the following steps: soaking a collagen material in a buffer solution containing DNA and a phosphate group activator, and incubating to obtain the modified collagen material. The material disclosed by the invention has immunoregulation and control performance aiming at Tregs, an anti-inflammatory microenvironment can be formed by regulating and controlling immunity, and the use performance of a collagen material as a dressing, a hemostatic material, an osteogenic material, artificial skin and the like is improved. 本发明公开了一种交联有DNA的胶原材料、制备方法及其应用。所述胶原材料上交联有DNA。所公开的制备方法是将胶原材料浸泡于含DNA和磷酸基团活化剂的缓冲液中，孵育后得到改性后的胶原材料。本发明的材料具有针对Tregs免疫调控性能，可以通过调控免疫，形成抑炎微环境，提升胶原材料作为敷料、止血材料、成骨材料和人工皮肤等的使用性能。