CELL MICROCHAMBER COMPRISING HUMAN CELLS IN THE PROCESS OF CARDIAC DIFFERENTIATION, TISSUE OBTAINED FROM

The present invention relates to cellular microcells, each comprising, sequentially organized around at least one cavity:-at least one inner layer of human cells during the differentiation of the cells into cardiac cells, expressing at least one gene selected from the group consisting of PDGFR [alpha], MESP-1, NKX2-5, GATA4, MEF2C, TBX20, ISL1, TBX5,-at least one intermediate layer of an isotonic aqueous solution, and-at least one outer layer of a hydrogel,-at least one inner layer of human cells, during the differentiation of the cells into cardiac cells, which expresses at least one gene selected from the group consisting of PDGFR [alpha], MESP-1, NKX2-5, GATA4, MEF2C, TBX20, ISL1, TBX5. The invention also relates to cardiac tissue obtained from these microcompartments and to the use thereof, in particular in the treatment of cardiac disorders. 本发明涉及细胞微区室，每个微区室包括围绕至少一个空腔依次组织的：-至少一层处于细胞分化成心脏细胞过程中的人细胞内层，其表达至少一种选自PDGFRα、MESP-1、NKX2-5、GATA4、MEF2C、TBX20、ISL1、TBX5的基因，-至少一层等渗水溶液中间层，以及-至少一层水凝胶外层。本发明还涉及从这些微区室获得的心脏组织