AAV vector for overexpressing nerve growth factor, recombinant virus and application thereof

The invention provides an AAV vector for overexpressing a nerve growth factor (NGF), a recombinant virus and application of the AAV vector and the recombinant virus, and belongs to the technical field of gene drugs. The invention provides an AAV vector for overexpressing nerve growth factors and a recombinant virus containing the AAV vector. The AAV vector or the recombinant virus can be used for preparing products for treating corneal nerve injury related diseases. The invention also provides an injection containing the AAV vector or the recombinant virus, the nerve growth factor can be continuously expressed in a target cell through one-time corneal stroma injection and maintained for more than 3 months, the defects of short action time, long-term high-frequency administration and recurrence of diseases after drug withdrawal of the traditional nerve growth factor eye drops are overcome, the requirement on patient compliance is low, and the application prospect is wide. And the method has a wider application