Tetrapeptides and compositions comprising tetrapeptides

Tetrapeptides and compositions comprising tetrapeptides

According to the invention, a tetrapeptide capable of inducing up-regulation of dermal extracellular matrix protein is provided, and the tetrapeptide has the following amino acid sequences: U-(SEQ ID No: 1)-Z, U-(SEQ ID No: 2)-Z, U-(SEQ ID No: 3)-Z, U-(SEQ ID No: 4)-Z, U-(SEQ ID No: 5)-Z, U-(SEQ ID...

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Hauptverfasser: EXLEY ALEXANDER, DUSCH YEGOR, SHERRATT MICHAEL JOHN, OZOLS MATHIS, BELL MICHAEL DAVID, BRADLEY ELEANOR JANE
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator EXLEY ALEXANDER
DUSCH YEGOR
SHERRATT MICHAEL JOHN
OZOLS MATHIS
BELL MICHAEL DAVID
BRADLEY ELEANOR JANE
description According to the invention, a tetrapeptide capable of inducing up-regulation of dermal extracellular matrix protein is provided, and the tetrapeptide has the following amino acid sequences: U-(SEQ ID No: 1)-Z, U-(SEQ ID No: 2)-Z, U-(SEQ ID No: 3)-Z, U-(SEQ ID No: 4)-Z, U-(SEQ ID No: 5)-Z, U-(SEQ ID No: 6)-Z, U-(SEQ ID No: 7)-Z, U-(SEQ ID No: 9)-Z, U-(SEQ ID No: 12)-Z, U-(SEQ ID No: 14)-Z, U-(SEQ ID No: 15)-Z, U-(SEQ ID No: 16)-Z, and U-(SEQ ID No: 1). Wherein, at the N-terminus, U is selected from the group consisting of CO-R1,-SO2-R1 or biotin-based groups, and, at the C-terminus, Z is selected from the group consisting of OH, OR1, NHR1 or NR1R2 wherein R1 and R2 are independently selected from the group consisting of alkyl, aryl, aralkyl, alkylaryl, alkoxy, sugar and aryloxy groups, the present invention relates to compounds which may be linear, branched, cyclic, polycyclic, unsaturated, hydroxylated, carbonylated, phosphorylated and/or sulfur-containing groups comprising from 1 to 24 carbon atoms and which
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Tetrapeptides and compositions comprising tetrapeptides
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