Application of alkannin emulsion in treatment and/or prevention of sepsis
The invention discloses an application of an alkannin emulsion in treating and/or preventing sepsis. The invention provides application of alkannin or an alkannin emulsion in preparation of a product for treating and/or preventing sepsis. The shikonin emulsion can improve the survival rate of mice w...
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| creator | HONG CHENGYING HUANG ZEWEI LIU XUEYAN YUAN LIJIA |
| description | The invention discloses an application of an alkannin emulsion in treating and/or preventing sepsis. The invention provides application of alkannin or an alkannin emulsion in preparation of a product for treating and/or preventing sepsis. The shikonin emulsion can improve the survival rate of mice with sepsis and reduce the generation level of inflammatory cytokines in serum of the mice with sepsis. In addition, it is found that the alkannin emulsion can reduce apoptosis of splenocytes and maintain the percentage of T cells of the spleen of a sepsis mouse. Further researches show that shikonin can reduce expression of PD-L1 on in-vivo and in-vitro macrophages, which is related to inhibition of expression of PKM2, nuclear translocation and combination with HRE sites of a PD-L1 promoter. Therefore, the shikonin emulsion disclosed by the invention possibly provides a potential therapeutic drug for the treatment of sepsis.
本发明公开了紫草素乳剂在治疗和/或预防脓毒症中的应用。本发明提供了紫草素或紫草素乳剂在制备用于治疗和/或预防脓毒症的产品中的应用。本发明紫草素乳剂可提高脓毒症小鼠的存活率，降低脓毒症 |
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本发明公开了紫草素乳剂在治疗和/或预防脓毒症中的应用。本发明提供了紫草素或紫草素乳剂在制备用于治疗和/或预防脓毒症的产品中的应用。本发明紫草素乳剂可提高脓毒症小鼠的存活率，降低脓毒症</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230829&DB=EPODOC&CC=CN&NR=116650454A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230829&DB=EPODOC&CC=CN&NR=116650454A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HONG CHENGYING</creatorcontrib><creatorcontrib>HUANG ZEWEI</creatorcontrib><creatorcontrib>LIU XUEYAN</creatorcontrib><creatorcontrib>YUAN LIJIA</creatorcontrib><title>Application of alkannin emulsion in treatment and/or prevention of sepsis</title><description>The invention discloses an application of an alkannin emulsion in treating and/or preventing sepsis. The invention provides application of alkannin or an alkannin emulsion in preparation of a product for treating and/or preventing sepsis. The shikonin emulsion can improve the survival rate of mice with sepsis and reduce the generation level of inflammatory cytokines in serum of the mice with sepsis. In addition, it is found that the alkannin emulsion can reduce apoptosis of splenocytes and maintain the percentage of T cells of the spleen of a sepsis mouse. Further researches show that shikonin can reduce expression of PD-L1 on in-vivo and in-vitro macrophages, which is related to inhibition of expression of PKM2, nuclear translocation and combination with HRE sites of a PD-L1 promoter. Therefore, the shikonin emulsion disclosed by the invention possibly provides a potential therapeutic drug for the treatment of sepsis.
本发明公开了紫草素乳剂在治疗和/或预防脓毒症中的应用。本发明提供了紫草素或紫草素乳剂在制备用于治疗和/或预防脓毒症的产品中的应用。本发明紫草素乳剂可提高脓毒症小鼠的存活率，降低脓毒症</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB0LCjIyUxOLMnMz1PIT1NIzMlOzMvLzFNIzS3NKQYJAtklRamJJbmpeSUKiXkp-vlFCgVFqWVALlRPcWpBcWYxDwNrWmJOcSovlOZmUHRzDXH20E0tyI9PLS5ITE7NSy2Jd_YzNDQzMzUwMTVxNCZGDQAEpzT1</recordid><startdate>20230829</startdate><enddate>20230829</enddate><creator>HONG CHENGYING</creator><creator>HUANG ZEWEI</creator><creator>LIU XUEYAN</creator><creator>YUAN LIJIA</creator><scope>EVB</scope></search><sort><creationdate>20230829</creationdate><title>Application of alkannin emulsion in treatment and/or prevention of sepsis</title><author>HONG CHENGYING ; HUANG ZEWEI ; LIU XUEYAN ; YUAN LIJIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116650454A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HONG CHENGYING</creatorcontrib><creatorcontrib>HUANG ZEWEI</creatorcontrib><creatorcontrib>LIU XUEYAN</creatorcontrib><creatorcontrib>YUAN LIJIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HONG CHENGYING</au><au>HUANG ZEWEI</au><au>LIU XUEYAN</au><au>YUAN LIJIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of alkannin emulsion in treatment and/or prevention of sepsis</title><date>2023-08-29</date><risdate>2023</risdate><abstract>The invention discloses an application of an alkannin emulsion in treating and/or preventing sepsis. The invention provides application of alkannin or an alkannin emulsion in preparation of a product for treating and/or preventing sepsis. The shikonin emulsion can improve the survival rate of mice with sepsis and reduce the generation level of inflammatory cytokines in serum of the mice with sepsis. In addition, it is found that the alkannin emulsion can reduce apoptosis of splenocytes and maintain the percentage of T cells of the spleen of a sepsis mouse. Further researches show that shikonin can reduce expression of PD-L1 on in-vivo and in-vitro macrophages, which is related to inhibition of expression of PKM2, nuclear translocation and combination with HRE sites of a PD-L1 promoter. Therefore, the shikonin emulsion disclosed by the invention possibly provides a potential therapeutic drug for the treatment of sepsis.
本发明公开了紫草素乳剂在治疗和/或预防脓毒症中的应用。本发明提供了紫草素或紫草素乳剂在制备用于治疗和/或预防脓毒症的产品中的应用。本发明紫草素乳剂可提高脓毒症小鼠的存活率，降低脓毒症</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Application of alkannin emulsion in treatment and/or prevention of sepsis |
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