Double-effect polymer micelle composite hydrogel as well as preparation method and application thereof

Double-effect polymer micelle composite hydrogel as well as preparation method and application thereof

The invention discloses a double-effect polymer micelle composite hydrogel as well as a preparation method and application thereof, and the method comprises the following steps: respectively chemically connecting raw materials including lenalidomide and hesperidin with end group modified polyethylen...

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Hauptverfasser: ZHOU MEILING, LIN YAN, JING PEI, BIAN TIERONG, WEI JUN, ZHONG ZHIRONG, LIU ZHONGBING, DU XINGJIE
Format: Patent
Sprache:chi ; eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator ZHOU MEILING
LIN YAN
JING PEI
BIAN TIERONG
WEI JUN
ZHONG ZHIRONG
LIU ZHONGBING
DU XINGJIE
description The invention discloses a double-effect polymer micelle composite hydrogel as well as a preparation method and application thereof, and the method comprises the following steps: respectively chemically connecting raw materials including lenalidomide and hesperidin with end group modified polyethylene glycol, and dissolving in dichloromethane to obtain a prodrug mixed solution; the preparation method comprises the following steps: dissolving a lenalidomide bulk drug and a hesperidin bulk drug in dichloromethane to obtain a drug solution; dissolving end group modified polyethylene glycol in dichloromethane to obtain a carrier solution; mixing the drug solution and the carrier solution, and then carrying out an emulsification self-assembly reaction under a water bath condition of 38-42 DEG C to obtain a double-drug-loaded micelle solution; and dissolving beta-sodium glycerophosphate in the prodrug mixed solution and the double-drug-loaded micelle solution, carrying out ice bath, and dropwise adding into a chitos
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Double-effect polymer micelle composite hydrogel as well as preparation method and application thereof
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