Anti-GTTR2-2 antibody and application thereof
The invention relates to the technical field of biological medicine, in particular to an anti-GTR2-2 antibody and application thereof, the code names of the anti-GTR2-2 antibody are B89, B108 and B168, and a heavy chain variable region of the anti-GTR2-2 antibody comprises a CDR-H1 with an amino aci...
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| creator | YU XUEJUN DI SHENGMENG LI ZHAORUN SHI LEI ZHAO ZUOSHUN FAN YANQIU |
| description | The invention relates to the technical field of biological medicine, in particular to an anti-GTR2-2 antibody and application thereof, the code names of the anti-GTR2-2 antibody are B89, B108 and B168, and a heavy chain variable region of the anti-GTR2-2 antibody comprises a CDR-H1 with an amino acid sequence as shown in SEQ ID No.1, SEQ ID No.23 or SEQ ID No.34, a CDR-H2 with an amino acid sequence as shown in SEQ ID No.2, SEQ ID No.24 or SEQ ID No.36 and a CDR-H3 with an amino acid sequence as shown in SEQ ID No.3, SEQ ID No.25 or SEQ ID No.38. The anti-GTR2-2 antibody has high affinity and can effectively target a tumor antigen GTR2-2, and a chimeric antigen recipient cell prepared by using the anti-GTR2-2 antibody can efficiently kill tumor cells and has high specificity.
本发明涉及生物医药技术领域，特别是涉及一种抗GTR2-2抗体及其应用，所述抗GTR2-2抗体代号为B89、B108和B168，所述抗GTR2-2抗体重链可变区包括氨基酸序列如SEQ IDNo.1、SEQ ID No.23或SEQ ID No.34所示的CDR-H1，如SEQ ID No.2、SEQ ID No.24或SEQ ID No.36所示的CDR-H2和如SEQ ID No.3、SEQ ID No.25或SEQ ID No.38所示的CDR-H3。所述抗GTR2- |
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本发明涉及生物医药技术领域，特别是涉及一种抗GTR2-2抗体及其应用，所述抗GTR2-2抗体代号为B89、B108和B168，所述抗GTR2-2抗体重链可变区包括氨基酸序列如SEQ IDNo.1、SEQ ID No.23或SEQ ID No.34所示的CDR-H1，如SEQ ID No.2、SEQ ID No.24或SEQ ID No.36所示的CDR-H2和如SEQ ID No.3、SEQ ID No.25或SEQ ID No.38所示的CDR-H3。所述抗GTR2-</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230825&DB=EPODOC&CC=CN&NR=116640217A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230825&DB=EPODOC&CC=CN&NR=116640217A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YU XUEJUN</creatorcontrib><creatorcontrib>DI SHENGMENG</creatorcontrib><creatorcontrib>LI ZHAORUN</creatorcontrib><creatorcontrib>SHI LEI</creatorcontrib><creatorcontrib>ZHAO ZUOSHUN</creatorcontrib><creatorcontrib>FAN YANQIU</creatorcontrib><title>Anti-GTTR2-2 antibody and application thereof</title><description>The invention relates to the technical field of biological medicine, in particular to an anti-GTR2-2 antibody and application thereof, the code names of the anti-GTR2-2 antibody are B89, B108 and B168, and a heavy chain variable region of the anti-GTR2-2 antibody comprises a CDR-H1 with an amino acid sequence as shown in SEQ ID No.1, SEQ ID No.23 or SEQ ID No.34, a CDR-H2 with an amino acid sequence as shown in SEQ ID No.2, SEQ ID No.24 or SEQ ID No.36 and a CDR-H3 with an amino acid sequence as shown in SEQ ID No.3, SEQ ID No.25 or SEQ ID No.38. The anti-GTR2-2 antibody has high affinity and can effectively target a tumor antigen GTR2-2, and a chimeric antigen recipient cell prepared by using the anti-GTR2-2 antibody can efficiently kill tumor cells and has high specificity.
本发明涉及生物医药技术领域，特别是涉及一种抗GTR2-2抗体及其应用，所述抗GTR2-2抗体代号为B89、B108和B168，所述抗GTR2-2抗体重链可变区包括氨基酸序列如SEQ IDNo.1、SEQ ID No.23或SEQ ID No.34所示的CDR-H1，如SEQ ID No.2、SEQ ID No.24或SEQ ID No.36所示的CDR-H2和如SEQ ID No.3、SEQ ID No.25或SEQ ID No.38所示的CDR-H3。所述抗GTR2-</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB1zCvJ1HUPCQky0jVSSARykvJTKoGMFIXEgoKczOTEksz8PIWSjNSi1Pw0HgbWtMSc4lReKM3NoOjmGuLsoZtakB-fWlyQmJyal1oS7-xnaGhmZmJgZGjuaEyMGgBGiikl</recordid><startdate>20230825</startdate><enddate>20230825</enddate><creator>YU XUEJUN</creator><creator>DI SHENGMENG</creator><creator>LI ZHAORUN</creator><creator>SHI LEI</creator><creator>ZHAO ZUOSHUN</creator><creator>FAN YANQIU</creator><scope>EVB</scope></search><sort><creationdate>20230825</creationdate><title>Anti-GTTR2-2 antibody and application thereof</title><author>YU XUEJUN ; DI SHENGMENG ; LI ZHAORUN ; SHI LEI ; ZHAO ZUOSHUN ; FAN YANQIU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116640217A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>YU XUEJUN</creatorcontrib><creatorcontrib>DI SHENGMENG</creatorcontrib><creatorcontrib>LI ZHAORUN</creatorcontrib><creatorcontrib>SHI LEI</creatorcontrib><creatorcontrib>ZHAO ZUOSHUN</creatorcontrib><creatorcontrib>FAN YANQIU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YU XUEJUN</au><au>DI SHENGMENG</au><au>LI ZHAORUN</au><au>SHI LEI</au><au>ZHAO ZUOSHUN</au><au>FAN YANQIU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Anti-GTTR2-2 antibody and application thereof</title><date>2023-08-25</date><risdate>2023</risdate><abstract>The invention relates to the technical field of biological medicine, in particular to an anti-GTR2-2 antibody and application thereof, the code names of the anti-GTR2-2 antibody are B89, B108 and B168, and a heavy chain variable region of the anti-GTR2-2 antibody comprises a CDR-H1 with an amino acid sequence as shown in SEQ ID No.1, SEQ ID No.23 or SEQ ID No.34, a CDR-H2 with an amino acid sequence as shown in SEQ ID No.2, SEQ ID No.24 or SEQ ID No.36 and a CDR-H3 with an amino acid sequence as shown in SEQ ID No.3, SEQ ID No.25 or SEQ ID No.38. The anti-GTR2-2 antibody has high affinity and can effectively target a tumor antigen GTR2-2, and a chimeric antigen recipient cell prepared by using the anti-GTR2-2 antibody can efficiently kill tumor cells and has high specificity.
本发明涉及生物医药技术领域，特别是涉及一种抗GTR2-2抗体及其应用，所述抗GTR2-2抗体代号为B89、B108和B168，所述抗GTR2-2抗体重链可变区包括氨基酸序列如SEQ IDNo.1、SEQ ID No.23或SEQ ID No.34所示的CDR-H1，如SEQ ID No.2、SEQ ID No.24或SEQ ID No.36所示的CDR-H2和如SEQ ID No.3、SEQ ID No.25或SEQ ID No.38所示的CDR-H3。所述抗GTR2-</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | Anti-GTTR2-2 antibody and application thereof |
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