Preparation process of (S)-nicotine
The invention discloses a preparation process for synthesizing (S)-nicotine, and belongs to the field of chemical synthesis. The novel (S)-nicotine synthesis method provided by the invention comprises the following steps: by taking 4-(3-pyridyl)-4-oxobutyraldehyde as an initial raw material and dich...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | GAO GUANGDONG SUN XU GAO LINGFENG ZHANG QILONG ZHOU YAN JUNG KYUNG-SOO FENG XIAONING RONG RAN |
| description | The invention discloses a preparation process for synthesizing (S)-nicotine, and belongs to the field of chemical synthesis. The novel (S)-nicotine synthesis method provided by the invention comprises the following steps: by taking 4-(3-pyridyl)-4-oxobutyraldehyde as an initial raw material and dichloro as a solvent, reacting with L-phenylalanine under the catalysis of acetic acid to generate a compound I; under the action of a Cu/ZnFe catalyst, hydrogen is introduced into the compound I by taking dichloromethane as a solvent, and the nicotine derivative is generated through hydrogenation; the method comprises the following steps: by taking palladium on carbon as a catalyst and dichloromethane as a solvent, carrying out hydrogenation reaction on a nicotine derivative, filtering palladium on carbon, adding formaldehyde, taking sodium borohydride as a reducing agent, reacting to generate nicotine, and purifying to obtain (S)-nicotine with the yield of 85.9% and the purity of 99.2%.
本发明公开了一种合成(S)-烟碱的制备工艺，属于化学合成领 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN116554143A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN116554143A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN116554143A3</originalsourceid><addsrcrecordid>eNrjZFAOKEotSCxKLMnMz1MoKMpPTi0uVshPU9AI1tTNy0zOL8nMS-VhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaGZqamJoYmxo7GxKgBALRFJek</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation process of (S)-nicotine</title><source>esp@cenet</source><creator>GAO GUANGDONG ; SUN XU ; GAO LINGFENG ; ZHANG QILONG ; ZHOU YAN ; JUNG KYUNG-SOO ; FENG XIAONING ; RONG RAN</creator><creatorcontrib>GAO GUANGDONG ; SUN XU ; GAO LINGFENG ; ZHANG QILONG ; ZHOU YAN ; JUNG KYUNG-SOO ; FENG XIAONING ; RONG RAN</creatorcontrib><description>The invention discloses a preparation process for synthesizing (S)-nicotine, and belongs to the field of chemical synthesis. The novel (S)-nicotine synthesis method provided by the invention comprises the following steps: by taking 4-(3-pyridyl)-4-oxobutyraldehyde as an initial raw material and dichloro as a solvent, reacting with L-phenylalanine under the catalysis of acetic acid to generate a compound I; under the action of a Cu/ZnFe catalyst, hydrogen is introduced into the compound I by taking dichloromethane as a solvent, and the nicotine derivative is generated through hydrogenation; the method comprises the following steps: by taking palladium on carbon as a catalyst and dichloromethane as a solvent, carrying out hydrogenation reaction on a nicotine derivative, filtering palladium on carbon, adding formaldehyde, taking sodium borohydride as a reducing agent, reacting to generate nicotine, and purifying to obtain (S)-nicotine with the yield of 85.9% and the purity of 99.2%.
本发明公开了一种合成(S)-烟碱的制备工艺，属于化学合成领</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230808&DB=EPODOC&CC=CN&NR=116554143A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230808&DB=EPODOC&CC=CN&NR=116554143A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GAO GUANGDONG</creatorcontrib><creatorcontrib>SUN XU</creatorcontrib><creatorcontrib>GAO LINGFENG</creatorcontrib><creatorcontrib>ZHANG QILONG</creatorcontrib><creatorcontrib>ZHOU YAN</creatorcontrib><creatorcontrib>JUNG KYUNG-SOO</creatorcontrib><creatorcontrib>FENG XIAONING</creatorcontrib><creatorcontrib>RONG RAN</creatorcontrib><title>Preparation process of (S)-nicotine</title><description>The invention discloses a preparation process for synthesizing (S)-nicotine, and belongs to the field of chemical synthesis. The novel (S)-nicotine synthesis method provided by the invention comprises the following steps: by taking 4-(3-pyridyl)-4-oxobutyraldehyde as an initial raw material and dichloro as a solvent, reacting with L-phenylalanine under the catalysis of acetic acid to generate a compound I; under the action of a Cu/ZnFe catalyst, hydrogen is introduced into the compound I by taking dichloromethane as a solvent, and the nicotine derivative is generated through hydrogenation; the method comprises the following steps: by taking palladium on carbon as a catalyst and dichloromethane as a solvent, carrying out hydrogenation reaction on a nicotine derivative, filtering palladium on carbon, adding formaldehyde, taking sodium borohydride as a reducing agent, reacting to generate nicotine, and purifying to obtain (S)-nicotine with the yield of 85.9% and the purity of 99.2%.
本发明公开了一种合成(S)-烟碱的制备工艺，属于化学合成领</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAOKEotSCxKLMnMz1MoKMpPTi0uVshPU9AI1tTNy0zOL8nMS-VhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoaGZqamJoYmxo7GxKgBALRFJek</recordid><startdate>20230808</startdate><enddate>20230808</enddate><creator>GAO GUANGDONG</creator><creator>SUN XU</creator><creator>GAO LINGFENG</creator><creator>ZHANG QILONG</creator><creator>ZHOU YAN</creator><creator>JUNG KYUNG-SOO</creator><creator>FENG XIAONING</creator><creator>RONG RAN</creator><scope>EVB</scope></search><sort><creationdate>20230808</creationdate><title>Preparation process of (S)-nicotine</title><author>GAO GUANGDONG ; SUN XU ; GAO LINGFENG ; ZHANG QILONG ; ZHOU YAN ; JUNG KYUNG-SOO ; FENG XIAONING ; RONG RAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116554143A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>GAO GUANGDONG</creatorcontrib><creatorcontrib>SUN XU</creatorcontrib><creatorcontrib>GAO LINGFENG</creatorcontrib><creatorcontrib>ZHANG QILONG</creatorcontrib><creatorcontrib>ZHOU YAN</creatorcontrib><creatorcontrib>JUNG KYUNG-SOO</creatorcontrib><creatorcontrib>FENG XIAONING</creatorcontrib><creatorcontrib>RONG RAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GAO GUANGDONG</au><au>SUN XU</au><au>GAO LINGFENG</au><au>ZHANG QILONG</au><au>ZHOU YAN</au><au>JUNG KYUNG-SOO</au><au>FENG XIAONING</au><au>RONG RAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation process of (S)-nicotine</title><date>2023-08-08</date><risdate>2023</risdate><abstract>The invention discloses a preparation process for synthesizing (S)-nicotine, and belongs to the field of chemical synthesis. The novel (S)-nicotine synthesis method provided by the invention comprises the following steps: by taking 4-(3-pyridyl)-4-oxobutyraldehyde as an initial raw material and dichloro as a solvent, reacting with L-phenylalanine under the catalysis of acetic acid to generate a compound I; under the action of a Cu/ZnFe catalyst, hydrogen is introduced into the compound I by taking dichloromethane as a solvent, and the nicotine derivative is generated through hydrogenation; the method comprises the following steps: by taking palladium on carbon as a catalyst and dichloromethane as a solvent, carrying out hydrogenation reaction on a nicotine derivative, filtering palladium on carbon, adding formaldehyde, taking sodium borohydride as a reducing agent, reacting to generate nicotine, and purifying to obtain (S)-nicotine with the yield of 85.9% and the purity of 99.2%.
本发明公开了一种合成(S)-烟碱的制备工艺，属于化学合成领</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN116554143A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Preparation process of (S)-nicotine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A38%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GAO%20GUANGDONG&rft.date=2023-08-08&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN116554143A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |