Indanone and indazolone derivatives with antioxidant activity as well as synthesis method and application of indanone and indazolone derivatives
The invention relates to indanone and indazolone derivatives with antioxidant activity and a synthesis method and application thereof, and the synthesis method comprises the following synthesis steps: by taking nickel trifluoromethanesulfonate as a catalyst, 1, 3-bis (2, 6-diisopropyl phenyl) imidaz...
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| creator | QIN XURONG LU JUN QIN TONG YUAN LYUJIANG REN QIAO ZENG MIN XU MAOTING DING JICHAO HUANG FULI ZHU MINGHUI |
| description | The invention relates to indanone and indazolone derivatives with antioxidant activity and a synthesis method and application thereof, and the synthesis method comprises the following synthesis steps: by taking nickel trifluoromethanesulfonate as a catalyst, 1, 3-bis (2, 6-diisopropyl phenyl) imidazole-2-ene (IPr) as a ligand, 1, 1, 3, 3-tetramethyldisiloxane as a hydrogen source, lithium tert-butoxide as an additive and 1, 4-dioxane as a solvent, carrying out a reaction at the temperature of 60-80 DEG C for 2-4 hours to obtain the indanone and indazolone derivatives with antioxidant activity. The method comprises the following steps: respectively carrying out intramolecular acyl reduction Heck cross-coupling on o-vinyl methyl benzoate and o-azo methyl benzoate derivatives, and characterizing the reduced Heck cross-coupling product by means of 1H NMR (nuclear magnetic resonance), 13C NMR (nuclear magnetic resonance), HRMS (high resolution mass spectrometry) and the like. A series of indanone and indazolone de |
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The method comprises the following steps: respectively carrying out intramolecular acyl reduction Heck cross-coupling on o-vinyl methyl benzoate and o-azo methyl benzoate derivatives, and characterizing the reduced Heck cross-coupling product by means of 1H NMR (nuclear magnetic resonance), 13C NMR (nuclear magnetic resonance), HRMS (high resolution mass spectrometry) and the like. 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The method comprises the following steps: respectively carrying out intramolecular acyl reduction Heck cross-coupling on o-vinyl methyl benzoate and o-azo methyl benzoate derivatives, and characterizing the reduced Heck cross-coupling product by means of 1H NMR (nuclear magnetic resonance), 13C NMR (nuclear magnetic resonance), HRMS (high resolution mass spectrometry) and the like. A series of indanone and indazolone de</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Indanone and indazolone derivatives with antioxidant activity as well as synthesis method and application of indanone and indazolone derivatives |
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