Method for efficiently synthesizing polysubstituted pyrroloquinoline compound
The invention provides a method for efficiently synthesizing a polysubstituted pyrroloquinoline compound, and belongs to the technical field of organic chemical preparation. The specific synthesis method is as follows: in an organic solution, nitrogen aryl propargyl substituted alpha-aminoketone is...
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| creator | YI NIANNIAN ZHANG BINBIN YI BING XIONG YI FANG ZHENGJUN DUAN YUXIN |
| description | The invention provides a method for efficiently synthesizing a polysubstituted pyrroloquinoline compound, and belongs to the technical field of organic chemical preparation. The specific synthesis method is as follows: in an organic solution, nitrogen aryl propargyl substituted alpha-aminoketone is used as a starting material, Hanss ester 1, 4-dihydropyridine is used as a hydrogen source, and under the action of a gold complex, the polysubstituted pyrroloquinoline compound is prepared in one step through cascade reaction of hydroarylation, transfer hydrogenation and dehydration cyclization in alkyne molecules. According to the invention, the raw materials are simpler and easier to obtain; according to the synthesis method, the reaction conditions are mild, the operation is simple, the reaction steps are few, the substrate application range is wide, the polysubstituted pyrroloquinoline compound is directly obtained through one-step reaction, and the yield is as high as 86%. The defect of raw material source li |
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The specific synthesis method is as follows: in an organic solution, nitrogen aryl propargyl substituted alpha-aminoketone is used as a starting material, Hanss ester 1, 4-dihydropyridine is used as a hydrogen source, and under the action of a gold complex, the polysubstituted pyrroloquinoline compound is prepared in one step through cascade reaction of hydroarylation, transfer hydrogenation and dehydration cyclization in alkyne molecules. According to the invention, the raw materials are simpler and easier to obtain; according to the synthesis method, the reaction conditions are mild, the operation is simple, the reaction steps are few, the substrate application range is wide, the polysubstituted pyrroloquinoline compound is directly obtained through one-step reaction, and the yield is as high as 86%. 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The specific synthesis method is as follows: in an organic solution, nitrogen aryl propargyl substituted alpha-aminoketone is used as a starting material, Hanss ester 1, 4-dihydropyridine is used as a hydrogen source, and under the action of a gold complex, the polysubstituted pyrroloquinoline compound is prepared in one step through cascade reaction of hydroarylation, transfer hydrogenation and dehydration cyclization in alkyne molecules. According to the invention, the raw materials are simpler and easier to obtain; according to the synthesis method, the reaction conditions are mild, the operation is simple, the reaction steps are few, the substrate application range is wide, the polysubstituted pyrroloquinoline compound is directly obtained through one-step reaction, and the yield is as high as 86%. 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The specific synthesis method is as follows: in an organic solution, nitrogen aryl propargyl substituted alpha-aminoketone is used as a starting material, Hanss ester 1, 4-dihydropyridine is used as a hydrogen source, and under the action of a gold complex, the polysubstituted pyrroloquinoline compound is prepared in one step through cascade reaction of hydroarylation, transfer hydrogenation and dehydration cyclization in alkyne molecules. According to the invention, the raw materials are simpler and easier to obtain; according to the synthesis method, the reaction conditions are mild, the operation is simple, the reaction steps are few, the substrate application range is wide, the polysubstituted pyrroloquinoline compound is directly obtained through one-step reaction, and the yield is as high as 86%. The defect of raw material source li</abstract><oa>free_for_read</oa></addata></record> |
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| title | Method for efficiently synthesizing polysubstituted pyrroloquinoline compound |
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