NANOPARTICLE COMPOSITIONS FOR TREATING CANCER

The present invention relates to nanoparticles and/or nanoparticle aggregates as well as compositions comprising nanoparticles and/or nanoparticle aggregates and their use in oncology. In particular, the nanoparticles and/or nanoparticle aggregates are radiopotentiators to be activated by ionizing radiation and are used in combination with at least one immunooncology (IO) agent to treat malignancies in human patients that fail to respond to previous immunotherapy and/or radiation therapy (RT) and undergo disease progression. 本发明涉及纳米颗粒和/或纳米颗粒聚集体以及包含纳米颗粒和/或纳米颗粒聚集体的组合物及它们在肿瘤学中的用途。具体而言，该纳米颗粒和/或纳米颗粒聚集体是要通过电离辐射激活的放射增强剂，并且与至少一种免疫肿瘤学(IO)剂组合用于治疗人类患者的恶性肿瘤，这些人类患者未能对先前的免疫疗法和/或放射疗法(RT)产生应答并且经历疾病进展。