Hydrogel microsphere with mechanical property and differentiation promoting function as well as preparation method and application of hydrogel microsphere
The invention discloses hydrogel microspheres with mechanical properties and a differentiation promoting function as well as a preparation method and application of the hydrogel microspheres. The preparation method of the hydrogel microspheres comprises the following steps: (1) synthesizing a photo-...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | LYU ZHENDONG CUI WENGUO CHEN HAO HWAH HAE-JONG ZHANG YUHUI CHEN ZEHAO |
| description | The invention discloses hydrogel microspheres with mechanical properties and a differentiation promoting function as well as a preparation method and application of the hydrogel microspheres. The preparation method of the hydrogel microspheres comprises the following steps: (1) synthesizing a photo-crosslinkable gelatin methacrylate prepolymer by using gelatin and methacrylic anhydride; (2) preparing GelMA hydrogel through a microfluidic device; (3) connecting fibronectin to the GelMA hydrogel obtained in the step (2), so as to obtain the fibronectin modified GelMA hydrogel; and (4) combining a platelet-derived growth factor-BB to the fibronectin-modified GelMA hydrogel obtained in the step (3), so as to obtain the hydrogel microspheres with both mechanical properties and differentiation promoting function. According to the hydrogel prepared by the invention, the contradiction that the existing hydrogel material needs lower modulus to better promote the differentiation of the nucleus pulposus stem cells and n |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN116492507A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN116492507A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN116492507A3</originalsourceid><addsrcrecordid>eNqNjr0KwjAUhbs4iPoO1wcQrL84SlE6ObnLJblpAvm5JJHSV_Fpbaujg9OB73wczrR41Z2MoSELzogYEmuKBK3JGhwJjd4ItMAxMMXcAXoJ0ijVSz4bzCb4oXQhG9-AenoxIkzQkrVDciTG-DEdZR3kOILMtp8ecVCgf7yYFxOFNtHim7Nieb3cq3pFHB6UGAV5yo_qVpaH3WmzXx_P23-cNy9EVLw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Hydrogel microsphere with mechanical property and differentiation promoting function as well as preparation method and application of hydrogel microsphere</title><source>esp@cenet</source><creator>LYU ZHENDONG ; CUI WENGUO ; CHEN HAO ; HWAH HAE-JONG ; ZHANG YUHUI ; CHEN ZEHAO</creator><creatorcontrib>LYU ZHENDONG ; CUI WENGUO ; CHEN HAO ; HWAH HAE-JONG ; ZHANG YUHUI ; CHEN ZEHAO</creatorcontrib><description>The invention discloses hydrogel microspheres with mechanical properties and a differentiation promoting function as well as a preparation method and application of the hydrogel microspheres. The preparation method of the hydrogel microspheres comprises the following steps: (1) synthesizing a photo-crosslinkable gelatin methacrylate prepolymer by using gelatin and methacrylic anhydride; (2) preparing GelMA hydrogel through a microfluidic device; (3) connecting fibronectin to the GelMA hydrogel obtained in the step (2), so as to obtain the fibronectin modified GelMA hydrogel; and (4) combining a platelet-derived growth factor-BB to the fibronectin-modified GelMA hydrogel obtained in the step (3), so as to obtain the hydrogel microspheres with both mechanical properties and differentiation promoting function. According to the hydrogel prepared by the invention, the contradiction that the existing hydrogel material needs lower modulus to better promote the differentiation of the nucleus pulposus stem cells and n</description><language>chi ; eng</language><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230728&DB=EPODOC&CC=CN&NR=116492507A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230728&DB=EPODOC&CC=CN&NR=116492507A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LYU ZHENDONG</creatorcontrib><creatorcontrib>CUI WENGUO</creatorcontrib><creatorcontrib>CHEN HAO</creatorcontrib><creatorcontrib>HWAH HAE-JONG</creatorcontrib><creatorcontrib>ZHANG YUHUI</creatorcontrib><creatorcontrib>CHEN ZEHAO</creatorcontrib><title>Hydrogel microsphere with mechanical property and differentiation promoting function as well as preparation method and application of hydrogel microsphere</title><description>The invention discloses hydrogel microspheres with mechanical properties and a differentiation promoting function as well as a preparation method and application of the hydrogel microspheres. The preparation method of the hydrogel microspheres comprises the following steps: (1) synthesizing a photo-crosslinkable gelatin methacrylate prepolymer by using gelatin and methacrylic anhydride; (2) preparing GelMA hydrogel through a microfluidic device; (3) connecting fibronectin to the GelMA hydrogel obtained in the step (2), so as to obtain the fibronectin modified GelMA hydrogel; and (4) combining a platelet-derived growth factor-BB to the fibronectin-modified GelMA hydrogel obtained in the step (3), so as to obtain the hydrogel microspheres with both mechanical properties and differentiation promoting function. According to the hydrogel prepared by the invention, the contradiction that the existing hydrogel material needs lower modulus to better promote the differentiation of the nucleus pulposus stem cells and n</description><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjr0KwjAUhbs4iPoO1wcQrL84SlE6ObnLJblpAvm5JJHSV_Fpbaujg9OB73wczrR41Z2MoSELzogYEmuKBK3JGhwJjd4ItMAxMMXcAXoJ0ijVSz4bzCb4oXQhG9-AenoxIkzQkrVDciTG-DEdZR3kOILMtp8ecVCgf7yYFxOFNtHim7Nieb3cq3pFHB6UGAV5yo_qVpaH3WmzXx_P23-cNy9EVLw</recordid><startdate>20230728</startdate><enddate>20230728</enddate><creator>LYU ZHENDONG</creator><creator>CUI WENGUO</creator><creator>CHEN HAO</creator><creator>HWAH HAE-JONG</creator><creator>ZHANG YUHUI</creator><creator>CHEN ZEHAO</creator><scope>EVB</scope></search><sort><creationdate>20230728</creationdate><title>Hydrogel microsphere with mechanical property and differentiation promoting function as well as preparation method and application of hydrogel microsphere</title><author>LYU ZHENDONG ; CUI WENGUO ; CHEN HAO ; HWAH HAE-JONG ; ZHANG YUHUI ; CHEN ZEHAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116492507A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><toplevel>online_resources</toplevel><creatorcontrib>LYU ZHENDONG</creatorcontrib><creatorcontrib>CUI WENGUO</creatorcontrib><creatorcontrib>CHEN HAO</creatorcontrib><creatorcontrib>HWAH HAE-JONG</creatorcontrib><creatorcontrib>ZHANG YUHUI</creatorcontrib><creatorcontrib>CHEN ZEHAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LYU ZHENDONG</au><au>CUI WENGUO</au><au>CHEN HAO</au><au>HWAH HAE-JONG</au><au>ZHANG YUHUI</au><au>CHEN ZEHAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Hydrogel microsphere with mechanical property and differentiation promoting function as well as preparation method and application of hydrogel microsphere</title><date>2023-07-28</date><risdate>2023</risdate><abstract>The invention discloses hydrogel microspheres with mechanical properties and a differentiation promoting function as well as a preparation method and application of the hydrogel microspheres. The preparation method of the hydrogel microspheres comprises the following steps: (1) synthesizing a photo-crosslinkable gelatin methacrylate prepolymer by using gelatin and methacrylic anhydride; (2) preparing GelMA hydrogel through a microfluidic device; (3) connecting fibronectin to the GelMA hydrogel obtained in the step (2), so as to obtain the fibronectin modified GelMA hydrogel; and (4) combining a platelet-derived growth factor-BB to the fibronectin-modified GelMA hydrogel obtained in the step (3), so as to obtain the hydrogel microspheres with both mechanical properties and differentiation promoting function. According to the hydrogel prepared by the invention, the contradiction that the existing hydrogel material needs lower modulus to better promote the differentiation of the nucleus pulposus stem cells and n</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN116492507A |
| source | esp@cenet |
| subjects | CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL |
| title | Hydrogel microsphere with mechanical property and differentiation promoting function as well as preparation method and application of hydrogel microsphere |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T07%3A41%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LYU%20ZHENDONG&rft.date=2023-07-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN116492507A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |