Target for treating age-related macular degeneration and antibody thereof
The invention discloses a target spot for treating age-related macular degeneration and an antibody thereof, and relates to the technical field of biomedicine.The gene target spot is obtained through screening from the ferroptosis mechanism of RPE cells, death of the RPE cells is inhibited through t...
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| creator | LIU DONGCHENG TAN YAO QIN BO LIU ZILING DANG LI HE FEN |
| description | The invention discloses a target spot for treating age-related macular degeneration and an antibody thereof, and relates to the technical field of biomedicine.The gene target spot is obtained through screening from the ferroptosis mechanism of RPE cells, death of the RPE cells is inhibited through the specific antibody, and then generation of AMD is inhibited; therefore, the compound is expected to be used as a potential therapeutic drug to provide a new thought for the treatment of dry AMD.
本发明公开了一种用于治疗年龄相关性黄斑变性的靶点及其抗体，涉及生物医药技术领域，本发明从RPE细胞的铁死亡机制出发，筛选得到基因靶点，并利用特异性抗体来抑制RPE细胞的死亡，进而抑制AMD的发生，从而有望作为潜在治疗药物为干性AMD的治疗提供新的思路。 |
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本发明公开了一种用于治疗年龄相关性黄斑变性的靶点及其抗体，涉及生物医药技术领域，本发明从RPE细胞的铁死亡机制出发，筛选得到基因靶点，并利用特异性抗体来抑制RPE细胞的死亡，进而抑制AMD的发生，从而有望作为潜在治疗药物为干性AMD的治疗提供新的思路。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230725&DB=EPODOC&CC=CN&NR=116474099A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230725&DB=EPODOC&CC=CN&NR=116474099A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU DONGCHENG</creatorcontrib><creatorcontrib>TAN YAO</creatorcontrib><creatorcontrib>QIN BO</creatorcontrib><creatorcontrib>LIU ZILING</creatorcontrib><creatorcontrib>DANG LI</creatorcontrib><creatorcontrib>HE FEN</creatorcontrib><title>Target for treating age-related macular degeneration and antibody thereof</title><description>The invention discloses a target spot for treating age-related macular degeneration and an antibody thereof, and relates to the technical field of biomedicine.The gene target spot is obtained through screening from the ferroptosis mechanism of RPE cells, death of the RPE cells is inhibited through the specific antibody, and then generation of AMD is inhibited; therefore, the compound is expected to be used as a potential therapeutic drug to provide a new thought for the treatment of dry AMD.
本发明公开了一种用于治疗年龄相关性黄斑变性的靶点及其抗体，涉及生物医药技术领域，本发明从RPE细胞的铁死亡机制出发，筛选得到基因靶点，并利用特异性抗体来抑制RPE细胞的死亡，进而抑制AMD的发生，从而有望作为潜在治疗药物为干性AMD的治疗提供新的思路。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMSSxKTy1RSMsvUigpSk0sycxLV0hMT9UtSs1JLElNUchNTC7NSSxSSElNT81LLQIqyM9TSMxLAeKSzKT8lEqFkozUotT8NB4G1rTEnOJUXijNzaDo5hri7KGbWpAfn1pckJgM1F8S7-xnaGhmYm5iYGnpaEyMGgDrJTTd</recordid><startdate>20230725</startdate><enddate>20230725</enddate><creator>LIU DONGCHENG</creator><creator>TAN YAO</creator><creator>QIN BO</creator><creator>LIU ZILING</creator><creator>DANG LI</creator><creator>HE FEN</creator><scope>EVB</scope></search><sort><creationdate>20230725</creationdate><title>Target for treating age-related macular degeneration and antibody thereof</title><author>LIU DONGCHENG ; TAN YAO ; QIN BO ; LIU ZILING ; DANG LI ; HE FEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116474099A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU DONGCHENG</creatorcontrib><creatorcontrib>TAN YAO</creatorcontrib><creatorcontrib>QIN BO</creatorcontrib><creatorcontrib>LIU ZILING</creatorcontrib><creatorcontrib>DANG LI</creatorcontrib><creatorcontrib>HE FEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU DONGCHENG</au><au>TAN YAO</au><au>QIN BO</au><au>LIU ZILING</au><au>DANG LI</au><au>HE FEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Target for treating age-related macular degeneration and antibody thereof</title><date>2023-07-25</date><risdate>2023</risdate><abstract>The invention discloses a target spot for treating age-related macular degeneration and an antibody thereof, and relates to the technical field of biomedicine.The gene target spot is obtained through screening from the ferroptosis mechanism of RPE cells, death of the RPE cells is inhibited through the specific antibody, and then generation of AMD is inhibited; therefore, the compound is expected to be used as a potential therapeutic drug to provide a new thought for the treatment of dry AMD.
本发明公开了一种用于治疗年龄相关性黄斑变性的靶点及其抗体，涉及生物医药技术领域，本发明从RPE细胞的铁死亡机制出发，筛选得到基因靶点，并利用特异性抗体来抑制RPE细胞的死亡，进而抑制AMD的发生，从而有望作为潜在治疗药物为干性AMD的治疗提供新的思路。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Target for treating age-related macular degeneration and antibody thereof |
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