Dissolvable matrix
Provided herein are dissolvable compositions having a porous matrix. The pore-forming excipient in the composition comprises two parts: saponin serving as a foaming agent; and a scaffolding agent selected from the group consisting of cellulose, starch and fibers. Additional excipients, such as pore...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | Provided herein are dissolvable compositions having a porous matrix. The pore-forming excipient in the composition comprises two parts: saponin serving as a foaming agent; and a scaffolding agent selected from the group consisting of cellulose, starch and fibers. Additional excipients, such as pore size modifiers, mineral ions, hygroscopicity modifiers, and emulsifiers, are added depending on the solubility, hygroscopicity, and lipophilicity of the active agent. The porous matrix is adapted to provide dissolvable formulations of prebiotics, bacteriophages, polyphenols, vitamins, plant extracts, and other nutritional supplements. Also provided herein are methods of making a soluble composition comprising mixing to a viscosity of 5000-12000 cP and depositing into a template or printing the composition into any desired shape.
本文提供了具有多孔基质的可溶解组合物。组合物中的造孔赋形剂有两部分:作为发泡剂的皂树皂苷;和选自纤维素、淀粉和纤维的支架剂。根据活性剂的溶解度、吸湿性和亲脂性来添加附加赋形剂,诸如孔径改性剂、矿物离子、吸湿性改性剂和乳化剂。多孔基质适于提供益生元、噬菌体、多酚、维生素、植物提取物和其他营养补充剂的可溶解制剂。本文还提供了制备可溶解组合物的方法,包括混合至5000-12000c |
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