Stable mometasone furoate cream and preparation method thereof

Stable mometasone furoate cream and preparation method thereof

The mometasone furoate cream provided by the invention only contains one emulsifier, the stability of the mometasone furoate cream can be remarkably improved, degradation of active ingredients and increase of impurity content can be reduced by virtue of the specific emulsifier hydrogenated soybean l...

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Hauptverfasser: YUAN LIXING, CHENG LU, DAI XIAOHUA, ZHU KEXU, WANG HAO, LIU XIAOQIONG
Format: Patent
Sprache:chi ; eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator YUAN LIXING
CHENG LU
DAI XIAOHUA
ZHU KEXU
WANG HAO
LIU XIAOQIONG
description The mometasone furoate cream provided by the invention only contains one emulsifier, the stability of the mometasone furoate cream can be remarkably improved, degradation of active ingredients and increase of impurity content can be reduced by virtue of the specific emulsifier hydrogenated soybean lecithin or mutual cooperation of soybean lecithin and a stabilizer edetate disodium, and the obtained cream is stable in performance, free of toxic and side effects and free of side effects. And the mometasone furoate cream is controllable in quality. Tests show that the mometasone furoate cream provided by the invention has stability superior to that of a commercially available product, namely, allocone, and can keep stable characters under the conditions of high temperature, high humidity, low temperature, freeze thawing and illumination, and maximum single impurities and total impurities in the product are not obviously increased. Meanwhile, the mometasone furoate cream disclosed by the invention is simple in pr
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Stable mometasone furoate cream and preparation method thereof
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