Large-size porous myocardial patch as well as preparation method and application thereof

The invention discloses a large-size porous myocardial patch as well as a preparation method and application thereof. The large-size porous myocardial patch prepared by the invention is good in size process stability, not easy to shrink and deform and stable in mechanical property, and the production period is shortened from the original several days to several hours; and the internal porosity is as high as 91%. Compared with a non-perforated patch, the perforated patch is more beneficial to migration and growth of cells towards the interior of the patch, so that angiogenesis on the patch is promoted during clinical application, and the cardiac function is repaired. 本发明公开了一种大尺寸多孔心肌补片及其制备方法和应用，本发明制备的大尺寸多孔心肌补片，尺寸的工艺稳定性好，产品不易收缩变形，力学性能稳定，生产周期由原来的几天缩短为几个小时；内部孔隙率高达91％。激光打孔补片与未打孔的补片相比，打孔补片更有利于细胞向补片内部的迁移、生长，从而有利于临床应用时促进补片上的血管生成，修复心功能。