Process for preparation of 1-methyl-6-[6-R2-5-methyl-8-(methylamino)-4-[(3aS, 6aS)-5-methyl-2, 3, 3a, 4, 6, 6a-hexahydropyrrolo [2, 3-c] pyrrol-1-yl]-9h-pyrido [2, 3-b] indol-3-yl]-4-oxo-1, 8-naphthyridine-3-carboxylic acid hydrochloride
The present invention relates to a process for the synthesis of compounds of formula (I) or diastereoisomers, pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or halogen; r2 is hydrogen, halogen or cyano; n is 0 to 7, in particular n is 2 to 3, more particularly n is 2; the compound...
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creator | CHEN WEICHUN ZHANG GUOCAI LIANG XING |
description | The present invention relates to a process for the synthesis of compounds of formula (I) or diastereoisomers, pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or halogen; r2 is hydrogen, halogen or cyano; n is 0 to 7, in particular n is 2 to 3, more particularly n is 2; the compound can be used for preventing and treating diseases caused by bacterial infection.
本发明涉及一种用于合成式(I)化合物或其非对映异构体、药用盐的方法,其中R1为氢或卤素;R2为氢、卤素或氰基;n为0至7,特别地n为2至3,更特别地n为2;其可用于预防和治疗由细菌感染引起的疾病。 |
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本发明涉及一种用于合成式(I)化合物或其非对映异构体、药用盐的方法,其中R1为氢或卤素;R2为氢、卤素或氰基;n为0至7,特别地n为2至3,更特别地n为2;其可用于预防和治疗由细菌感染引起的疾病。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230707&DB=EPODOC&CC=CN&NR=116406365A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230707&DB=EPODOC&CC=CN&NR=116406365A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN WEICHUN</creatorcontrib><creatorcontrib>ZHANG GUOCAI</creatorcontrib><creatorcontrib>LIANG XING</creatorcontrib><title>Process for preparation of 1-methyl-6-[6-R2-5-methyl-8-(methylamino)-4-[(3aS, 6aS)-5-methyl-2, 3, 3a, 4, 6, 6a-hexahydropyrrolo [2, 3-c] pyrrol-1-yl]-9h-pyrido [2, 3-b] indol-3-yl]-4-oxo-1, 8-naphthyridine-3-carboxylic acid hydrochloride</title><description>The present invention relates to a process for the synthesis of compounds of formula (I) or diastereoisomers, pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or halogen; r2 is hydrogen, halogen or cyano; n is 0 to 7, in particular n is 2 to 3, more particularly n is 2; the compound can be used for preventing and treating diseases caused by bacterial infection.
本发明涉及一种用于合成式(I)化合物或其非对映异构体、药用盐的方法,其中R1为氢或卤素;R2为氢、卤素或氰基;n为0至7,特别地n为2至3,更特别地n为2;其可用于预防和治疗由细菌感染引起的疾病。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjcFqwzAMhnPZYax7B_XWQgRLk5ruWMrGTmOsu4VQVEfBBtcyTg7JQ-8d5rYruw4Ekv7vg_8--_6IornvoZMIIXKgSIMVD9JBgScezORQYa3wc4XrW7DBxfWik_WyxArrRUn7HBTtl3_aKocyDeVQJXSmaHgkM7VRwhSjOIH6LKFu4BpggZNr8Nlg-m1748cGrG8TLi-4QhkFixw26CmYVJZc6zlhTfEo4-SsBtK2hUuZNk6SwbPsriPX8-Pvfsjmry9fuzfkIAfuA2n2PBx270WhqidVqvW2_I_zA5avZ1Q</recordid><startdate>20230707</startdate><enddate>20230707</enddate><creator>CHEN WEICHUN</creator><creator>ZHANG GUOCAI</creator><creator>LIANG XING</creator><scope>EVB</scope></search><sort><creationdate>20230707</creationdate><title>Process for preparation of 1-methyl-6-[6-R2-5-methyl-8-(methylamino)-4-[(3aS, 6aS)-5-methyl-2, 3, 3a, 4, 6, 6a-hexahydropyrrolo [2, 3-c] pyrrol-1-yl]-9h-pyrido [2, 3-b] indol-3-yl]-4-oxo-1, 8-naphthyridine-3-carboxylic acid hydrochloride</title><author>CHEN WEICHUN ; ZHANG GUOCAI ; LIANG XING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116406365A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN WEICHUN</creatorcontrib><creatorcontrib>ZHANG GUOCAI</creatorcontrib><creatorcontrib>LIANG XING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN WEICHUN</au><au>ZHANG GUOCAI</au><au>LIANG XING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for preparation of 1-methyl-6-[6-R2-5-methyl-8-(methylamino)-4-[(3aS, 6aS)-5-methyl-2, 3, 3a, 4, 6, 6a-hexahydropyrrolo [2, 3-c] pyrrol-1-yl]-9h-pyrido [2, 3-b] indol-3-yl]-4-oxo-1, 8-naphthyridine-3-carboxylic acid hydrochloride</title><date>2023-07-07</date><risdate>2023</risdate><abstract>The present invention relates to a process for the synthesis of compounds of formula (I) or diastereoisomers, pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or halogen; r2 is hydrogen, halogen or cyano; n is 0 to 7, in particular n is 2 to 3, more particularly n is 2; the compound can be used for preventing and treating diseases caused by bacterial infection.
本发明涉及一种用于合成式(I)化合物或其非对映异构体、药用盐的方法,其中R1为氢或卤素;R2为氢、卤素或氰基;n为0至7,特别地n为2至3,更特别地n为2;其可用于预防和治疗由细菌感染引起的疾病。</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
title | Process for preparation of 1-methyl-6-[6-R2-5-methyl-8-(methylamino)-4-[(3aS, 6aS)-5-methyl-2, 3, 3a, 4, 6, 6a-hexahydropyrrolo [2, 3-c] pyrrol-1-yl]-9h-pyrido [2, 3-b] indol-3-yl]-4-oxo-1, 8-naphthyridine-3-carboxylic acid hydrochloride |
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