Method for extracting and splitting raceme compound by enantioselective reverse micelle

The invention discloses a method for preparing a chiral compound by extracting and splitting a raceme compound through enantioselective reverse micelles. According to the resolution method, reverse micelles are formed in a non-aqueous solvent which is insoluble in water by using a chiral amino acid surfactant, and enantiomers in a raceme compound in a water phase are selectively extracted so as to separate the raceme compound. The method for preparing the chiral compound through enantioselective reverse micelle extraction and resolution of the raceme compound has the characteristics of simple resolution process, simple and convenient process operation, high enantioselectivity, reusable reverse micelle, low resolution cost and the like, meets the requirements of large-scale resolution, and opens up a new way for chiral resolution. 本发明公开了一种对映选择性反胶团萃取拆分外消旋体化合物制备手性化合物的方法。所述拆分方法以手性氨基酸表面活性剂在难溶于水的非水溶剂中形成反胶团，对水相中外消旋体化合物中的对映体实现选择性萃取而分离外消旋体化合物。所述的对映选择性反胶束萃取拆分外消旋体化合物制备手性化合物的方法，具有拆分工艺简单、工艺操作简便、对映选择性高、反胶团可重复使用和拆分成本低等特点，适用