Pharmaceutical compositions
具有改善的稳定性和对凝聚、颗粒形成和沉淀的抑制作用的多肽药物组合物，所述组合物包含一种多肽药物和poloxamer表面活性剂或poloxamer表面活性剂与聚氧乙烯脱水山梨醇脂肪酸酯表面活性剂的混合物。优选的被稳定的多肽是杀菌/渗透性增强(BPI)蛋白、BPI的生物活性片段、BPI的生物活性类似物以及BPI的生物活性变种。 Bactericidal/permeability increasing (BPI) polypeptide pharmaceutical compositions having improved stability and resistance to aggregatio...
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| creator | WELDON COURTNEY MCGREGOR,JAMES STUBSTAD,PAUL CHANG |
| description | 具有改善的稳定性和对凝聚、颗粒形成和沉淀的抑制作用的多肽药物组合物，所述组合物包含一种多肽药物和poloxamer表面活性剂或poloxamer表面活性剂与聚氧乙烯脱水山梨醇脂肪酸酯表面活性剂的混合物。优选的被稳定的多肽是杀菌/渗透性增强(BPI)蛋白、BPI的生物活性片段、BPI的生物活性类似物以及BPI的生物活性变种。
Bactericidal/permeability increasing (BPI) polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising the polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate suractants. Preferred BPI polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, and biologically active analogs of BPI. |
| format | Patent |
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Bactericidal/permeability increasing (BPI) polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising the polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate suractants. Preferred BPI polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, and biologically active analogs of BPI.</description><edition>7</edition><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040825&DB=EPODOC&CC=CN&NR=1163264C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040825&DB=EPODOC&CC=CN&NR=1163264C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WELDON COURTNEY MCGREGOR,JAMES STUBSTAD,PAUL CHANG</creatorcontrib><title>Pharmaceutical compositions</title><description>具有改善的稳定性和对凝聚、颗粒形成和沉淀的抑制作用的多肽药物组合物，所述组合物包含一种多肽药物和poloxamer表面活性剂或poloxamer表面活性剂与聚氧乙烯脱水山梨醇脂肪酸酯表面活性剂的混合物。优选的被稳定的多肽是杀菌/渗透性增强(BPI)蛋白、BPI的生物活性片段、BPI的生物活性类似物以及BPI的生物活性变种。
Bactericidal/permeability increasing (BPI) polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising the polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate suractants. Preferred BPI polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, and biologically active analogs of BPI.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAOyEgsyk1MTi0tyUxOzFFIzs8tyC_OLMnMzyvmYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQVAXXmpJfHOfoaGZsZGZibOzsZEKAEAZ9sjog</recordid><startdate>20040825</startdate><enddate>20040825</enddate><creator>WELDON COURTNEY MCGREGOR,JAMES STUBSTAD,PAUL CHANG</creator><scope>EVB</scope></search><sort><creationdate>20040825</creationdate><title>Pharmaceutical compositions</title><author>WELDON COURTNEY MCGREGOR,JAMES STUBSTAD,PAUL CHANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1163264CC3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2004</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WELDON COURTNEY MCGREGOR,JAMES STUBSTAD,PAUL CHANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WELDON COURTNEY MCGREGOR,JAMES STUBSTAD,PAUL CHANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pharmaceutical compositions</title><date>2004-08-25</date><risdate>2004</risdate><abstract>具有改善的稳定性和对凝聚、颗粒形成和沉淀的抑制作用的多肽药物组合物，所述组合物包含一种多肽药物和poloxamer表面活性剂或poloxamer表面活性剂与聚氧乙烯脱水山梨醇脂肪酸酯表面活性剂的混合物。优选的被稳定的多肽是杀菌/渗透性增强(BPI)蛋白、BPI的生物活性片段、BPI的生物活性类似物以及BPI的生物活性变种。
Bactericidal/permeability increasing (BPI) polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising the polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate suractants. Preferred BPI polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, and biologically active analogs of BPI.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Pharmaceutical compositions |
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