Improved industrial method for extracting alpha yohimbine from plants of genus rauvolfia and extracts thereof

Improved industrial method for extracting alpha yohimbine from plants of genus rauvolfia and extracts thereof

The invention relates to an improved industrial method for extracting alpha yohimbine from a plant of the genus Prauwolfia and an extract of the alpha yohimbine. The invention discloses an improved process for extracting alpha-yohimbine from leaves of rauvolfia plants, and preferably, rauvolfia cara...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: CHAUHAN ASHOK KUMAR, TEWARI KIRAN, MANOJ. BALLY
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator CHAUHAN ASHOK KUMAR
TEWARI KIRAN
MANOJ. BALLY
description The invention relates to an improved industrial method for extracting alpha yohimbine from a plant of the genus Prauwolfia and an extract of the alpha yohimbine. The invention discloses an improved process for extracting alpha-yohimbine from leaves of rauvolfia plants, and preferably, rauvolfia caraway/rauvolfia tetrafolia. The process involves precipitating a compound of interest using a non-polar alcohol solvent, such as methanol, repeatedly washing with a halogenated solvent, and washing with hexane or petroleum ether to obtain a high purity extract in high yields. Use of organic acids such as tartaric acid and acetic acid and an organic solvent acetic ether is omitted, so that the process is low in time consumption and economical. The yield of the final product is 50-60% higher than that of the prior art, namely 600-670 mg/100 g of dry leaves. Furthermore, the extract obtained by the method of the present invention comprises yohimbine hydrochloride as a labelling compound, whose analytically detectable am
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN116323605A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN116323605A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN116323605A3</originalsourceid><addsrcrecordid>eNqNyzEOwjAMQNEuDAi4gzkAEqWiO6pAsDCxV6ZxmkhJHDluBbdngZ3pL-8vq3iLWXgmAz6Zqah4DBBJHRuwLEAvFRzUpxEwZIfwZufj0ycCKxwhB0xagC2MlKYCgtPMwXoETOZ3F1BHQmzX1cJiKLT5dlVtL-dHd91R5p5KxoESad_d67ptDk27P56af8wH6ElC7g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Improved industrial method for extracting alpha yohimbine from plants of genus rauvolfia and extracts thereof</title><source>esp@cenet</source><creator>CHAUHAN ASHOK KUMAR ; TEWARI KIRAN ; MANOJ. BALLY</creator><creatorcontrib>CHAUHAN ASHOK KUMAR ; TEWARI KIRAN ; MANOJ. BALLY</creatorcontrib><description>The invention relates to an improved industrial method for extracting alpha yohimbine from a plant of the genus Prauwolfia and an extract of the alpha yohimbine. The invention discloses an improved process for extracting alpha-yohimbine from leaves of rauvolfia plants, and preferably, rauvolfia caraway/rauvolfia tetrafolia. The process involves precipitating a compound of interest using a non-polar alcohol solvent, such as methanol, repeatedly washing with a halogenated solvent, and washing with hexane or petroleum ether to obtain a high purity extract in high yields. Use of organic acids such as tartaric acid and acetic acid and an organic solvent acetic ether is omitted, so that the process is low in time consumption and economical. The yield of the final product is 50-60% higher than that of the prior art, namely 600-670 mg/100 g of dry leaves. Furthermore, the extract obtained by the method of the present invention comprises yohimbine hydrochloride as a labelling compound, whose analytically detectable am</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20230623&amp;DB=EPODOC&amp;CC=CN&amp;NR=116323605A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20230623&amp;DB=EPODOC&amp;CC=CN&amp;NR=116323605A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAUHAN ASHOK KUMAR</creatorcontrib><creatorcontrib>TEWARI KIRAN</creatorcontrib><creatorcontrib>MANOJ. BALLY</creatorcontrib><title>Improved industrial method for extracting alpha yohimbine from plants of genus rauvolfia and extracts thereof</title><description>The invention relates to an improved industrial method for extracting alpha yohimbine from a plant of the genus Prauwolfia and an extract of the alpha yohimbine. The invention discloses an improved process for extracting alpha-yohimbine from leaves of rauvolfia plants, and preferably, rauvolfia caraway/rauvolfia tetrafolia. The process involves precipitating a compound of interest using a non-polar alcohol solvent, such as methanol, repeatedly washing with a halogenated solvent, and washing with hexane or petroleum ether to obtain a high purity extract in high yields. Use of organic acids such as tartaric acid and acetic acid and an organic solvent acetic ether is omitted, so that the process is low in time consumption and economical. The yield of the final product is 50-60% higher than that of the prior art, namely 600-670 mg/100 g of dry leaves. Furthermore, the extract obtained by the method of the present invention comprises yohimbine hydrochloride as a labelling compound, whose analytically detectable am</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyzEOwjAMQNEuDAi4gzkAEqWiO6pAsDCxV6ZxmkhJHDluBbdngZ3pL-8vq3iLWXgmAz6Zqah4DBBJHRuwLEAvFRzUpxEwZIfwZufj0ycCKxwhB0xagC2MlKYCgtPMwXoETOZ3F1BHQmzX1cJiKLT5dlVtL-dHd91R5p5KxoESad_d67ptDk27P56af8wH6ElC7g</recordid><startdate>20230623</startdate><enddate>20230623</enddate><creator>CHAUHAN ASHOK KUMAR</creator><creator>TEWARI KIRAN</creator><creator>MANOJ. BALLY</creator><scope>EVB</scope></search><sort><creationdate>20230623</creationdate><title>Improved industrial method for extracting alpha yohimbine from plants of genus rauvolfia and extracts thereof</title><author>CHAUHAN ASHOK KUMAR ; TEWARI KIRAN ; MANOJ. BALLY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116323605A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>CHAUHAN ASHOK KUMAR</creatorcontrib><creatorcontrib>TEWARI KIRAN</creatorcontrib><creatorcontrib>MANOJ. BALLY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHAUHAN ASHOK KUMAR</au><au>TEWARI KIRAN</au><au>MANOJ. BALLY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Improved industrial method for extracting alpha yohimbine from plants of genus rauvolfia and extracts thereof</title><date>2023-06-23</date><risdate>2023</risdate><abstract>The invention relates to an improved industrial method for extracting alpha yohimbine from a plant of the genus Prauwolfia and an extract of the alpha yohimbine. The invention discloses an improved process for extracting alpha-yohimbine from leaves of rauvolfia plants, and preferably, rauvolfia caraway/rauvolfia tetrafolia. The process involves precipitating a compound of interest using a non-polar alcohol solvent, such as methanol, repeatedly washing with a halogenated solvent, and washing with hexane or petroleum ether to obtain a high purity extract in high yields. Use of organic acids such as tartaric acid and acetic acid and an organic solvent acetic ether is omitted, so that the process is low in time consumption and economical. The yield of the final product is 50-60% higher than that of the prior art, namely 600-670 mg/100 g of dry leaves. Furthermore, the extract obtained by the method of the present invention comprises yohimbine hydrochloride as a labelling compound, whose analytically detectable am</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN116323605A
source esp@cenet
subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Improved industrial method for extracting alpha yohimbine from plants of genus rauvolfia and extracts thereof
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T11%3A41%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CHAUHAN%20ASHOK%20KUMAR&rft.date=2023-06-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN116323605A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true