Method for efficiently converting crystalline cefuroxime axetil into amorphous powder and product

The invention discloses a method for converting high-efficiency crystalline cefuroxime axetil into amorphous powder and a product, and the method comprises the following steps: S1, adding cefuroxime axetil crystalline powder into anhydrous acetone, stirring and dissolving, and controlling the temperature; s2, performing low-temperature vacuum concentration to a semi-molten state; s3, the semi-molten liquid is rapidly poured into a crystallizer at a time, isopropyl ether or water is contained in the crystallizer, and rapid stirring is conducted; and S4, stirring for a period of time, filtering, washing and drying to obtain an amorphous cefuroxime axetil product with the particle size of 300-800nm. According to the invention, the conversion rate can be greatly improved, crystalline cefuroxime axetil residues are reduced, and the bioavailability of cefuroxime axetil is improved; meanwhile, the dosage of anti-solvent isopropyl ether or water is reduced, and a solvent system is small. 本发明公开了一种高效率结晶型头孢呋辛酯转无定型粉体的方法及