Preparation method of pazufloxacin mesylate liquid preparation

The invention provides a preparation method of a pazufloxacin mesilate liquid preparation, and belongs to the technical field of pharmaceutical preparations. In the implementation process, by adjusting the preparation method of the liquid preparation, especially controlling the adding sequence of all the components, the dissolving effect of the medicine components is obviously improved, and the clarity of the prepared pazufloxacin mesylate liquid preparation is obviously improved; besides, the stability of the prepared pazufloxacin mesylate liquid preparation can be obviously improved by reasonably controlling the addition amount of the components and the ratio of the components, namely controlling the mass ratio of the sodium dihydrogen phosphate to the disodium hydrogen phosphate to the sodium hyaluronate. 本申请提供了一种甲磺酸帕珠沙星液体制剂的制备方法，属于药物制剂技术领域。本申请在实施过程中通过调整液体制剂的制备方法，尤其是控制各组分的加入顺序，明显提高了药物组分的溶解效果，使制备得到的甲磺酸帕珠沙星液体制剂的澄清度明显提高；另外，本申请通过合理控制各组分的添加量，合理控制各组分之间的配比，即控制磷酸二氢钠、磷酸氢二钠和玻璃酸钠的质量比，能够使制备的甲磺酸帕珠沙星液体制剂的稳定性明显提高。