Separation method of clindamycin phosphate and product thereof

The invention provides a separation method of clindamycin phosphate and a product thereof, and belongs to the technical field of clindamycin phosphate. Comprising the following steps: (1) adding alkaline water into clindamycin phosphate reaction hydrolysate, adjusting the pH value of a system, addin...

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Hauptverfasser: AN JIAFENG, NIAN BEILEI, YU YOUYANG, ZHANG ZHANSHENG, CAO YUNFENG, REN QINGHUA, WANG YANAN, ZHAO ZHEN, LIU JIFANG, JIN PENGFEI, CAO LINLIN, XUE JUAN, ZHANG NIAN, FAN YINGLEI, LIU XIAOGUANG
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creator AN JIAFENG
NIAN BEILEI
YU YOUYANG
ZHANG ZHANSHENG
CAO YUNFENG
REN QINGHUA
WANG YANAN
ZHAO ZHEN
LIU JIFANG
JIN PENGFEI
CAO LINLIN
XUE JUAN
ZHANG NIAN
FAN YINGLEI
LIU XIAOGUANG
description The invention provides a separation method of clindamycin phosphate and a product thereof, and belongs to the technical field of clindamycin phosphate. Comprising the following steps: (1) adding alkaline water into clindamycin phosphate reaction hydrolysate, adjusting the pH value of a system, adding a precipitation reagent, reacting to generate a precipitate, and filtering to obtain a clindamycin phosphate precipitate; (2) adding the clindamycin phosphate precipitate into water and ethanol, stirring and heating, adding concentrated hydrochloric acid until the precipitate is completely dissolved, controlling the pH value of the system to be 3.5-4.5, adding activated carbon for decoloration, and filtering out the activated carbon and insoluble impurities while the solution is hot to obtain a decolorized solution; and (3) adding ethanol into the decolored solution, stirring, cooling, crystallizing, filtering and drying to obtain clindamycin phosphate. The preparation process is simple to operate and low in ener
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subjects CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
title Separation method of clindamycin phosphate and product thereof
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