Application of oncolytic adenovirus expressing bispecific antibody in combination with CART in tumor treatment
The invention belongs to the technical field of biological medicines, and particularly relates to application of oncolytic adenovirus expressing a bispecific antibody in combination with CART in tumor treatment. The invention provides combined application of three tumor immunotherapies of oncolytic...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | WU HUAN WANG QIUMAN KONG BEIHUA YAN SHI SONG KUN LI RONGRONG YUAN CUNZHONG ZHANG QING |
| description | The invention belongs to the technical field of biological medicines, and particularly relates to application of oncolytic adenovirus expressing a bispecific antibody in combination with CART in tumor treatment. The invention provides combined application of three tumor immunotherapies of oncolytic adenovirus, a bispecific antibody and CART (chimeric antigen receptor T). The recombinant oncolytic adenovirus expresses and secretes MUC16-BiTE, and the MUC16-BiTE can bridge tumor cells and CART cells, induce immune synapse formation and stimulate CART cell activation; the recombinant oncolytic adenovirus can dissolve tumor cells, increase CART cell infiltration, generate a pro-inflammatory environment, promote solid tumor immune activation and overcome tumor immunosuppression. The MUC16-BiTE obtained after recombination can target a CART cell CD3 antigen and a tumor cell MUC16 antigen at the same time, the targeting performance of the CART is enhanced, meanwhile, adverse reactions caused by systemic administrati |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN116196402A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN116196402A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN116196402A3</originalsourceid><addsrcrecordid>eNqNjDEKwkAQANNYiPqH9QGCpxKwDEGxspD04e6y0YVk97jbqPm9BH2A1RQzzDzjIoSOvFUSBmlB2Es3KnmwDbI8KQ4J8B0ipkR8B0cpoKd2CljJSTMCMXjpHfH38iJ9QFncqkno0EsEjWi1R9ZlNmttl3D14yJbn09VedlgkBpTsB4ZtS6vxuTmmB-2u2L_T_MBMjhDMw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Application of oncolytic adenovirus expressing bispecific antibody in combination with CART in tumor treatment</title><source>esp@cenet</source><creator>WU HUAN ; WANG QIUMAN ; KONG BEIHUA ; YAN SHI ; SONG KUN ; LI RONGRONG ; YUAN CUNZHONG ; ZHANG QING</creator><creatorcontrib>WU HUAN ; WANG QIUMAN ; KONG BEIHUA ; YAN SHI ; SONG KUN ; LI RONGRONG ; YUAN CUNZHONG ; ZHANG QING</creatorcontrib><description>The invention belongs to the technical field of biological medicines, and particularly relates to application of oncolytic adenovirus expressing a bispecific antibody in combination with CART in tumor treatment. The invention provides combined application of three tumor immunotherapies of oncolytic adenovirus, a bispecific antibody and CART (chimeric antigen receptor T). The recombinant oncolytic adenovirus expresses and secretes MUC16-BiTE, and the MUC16-BiTE can bridge tumor cells and CART cells, induce immune synapse formation and stimulate CART cell activation; the recombinant oncolytic adenovirus can dissolve tumor cells, increase CART cell infiltration, generate a pro-inflammatory environment, promote solid tumor immune activation and overcome tumor immunosuppression. The MUC16-BiTE obtained after recombination can target a CART cell CD3 antigen and a tumor cell MUC16 antigen at the same time, the targeting performance of the CART is enhanced, meanwhile, adverse reactions caused by systemic administrati</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230602&DB=EPODOC&CC=CN&NR=116196402A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230602&DB=EPODOC&CC=CN&NR=116196402A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WU HUAN</creatorcontrib><creatorcontrib>WANG QIUMAN</creatorcontrib><creatorcontrib>KONG BEIHUA</creatorcontrib><creatorcontrib>YAN SHI</creatorcontrib><creatorcontrib>SONG KUN</creatorcontrib><creatorcontrib>LI RONGRONG</creatorcontrib><creatorcontrib>YUAN CUNZHONG</creatorcontrib><creatorcontrib>ZHANG QING</creatorcontrib><title>Application of oncolytic adenovirus expressing bispecific antibody in combination with CART in tumor treatment</title><description>The invention belongs to the technical field of biological medicines, and particularly relates to application of oncolytic adenovirus expressing a bispecific antibody in combination with CART in tumor treatment. The invention provides combined application of three tumor immunotherapies of oncolytic adenovirus, a bispecific antibody and CART (chimeric antigen receptor T). The recombinant oncolytic adenovirus expresses and secretes MUC16-BiTE, and the MUC16-BiTE can bridge tumor cells and CART cells, induce immune synapse formation and stimulate CART cell activation; the recombinant oncolytic adenovirus can dissolve tumor cells, increase CART cell infiltration, generate a pro-inflammatory environment, promote solid tumor immune activation and overcome tumor immunosuppression. The MUC16-BiTE obtained after recombination can target a CART cell CD3 antigen and a tumor cell MUC16 antigen at the same time, the targeting performance of the CART is enhanced, meanwhile, adverse reactions caused by systemic administrati</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEKwkAQANNYiPqH9QGCpxKwDEGxspD04e6y0YVk97jbqPm9BH2A1RQzzDzjIoSOvFUSBmlB2Es3KnmwDbI8KQ4J8B0ipkR8B0cpoKd2CljJSTMCMXjpHfH38iJ9QFncqkno0EsEjWi1R9ZlNmttl3D14yJbn09VedlgkBpTsB4ZtS6vxuTmmB-2u2L_T_MBMjhDMw</recordid><startdate>20230602</startdate><enddate>20230602</enddate><creator>WU HUAN</creator><creator>WANG QIUMAN</creator><creator>KONG BEIHUA</creator><creator>YAN SHI</creator><creator>SONG KUN</creator><creator>LI RONGRONG</creator><creator>YUAN CUNZHONG</creator><creator>ZHANG QING</creator><scope>EVB</scope></search><sort><creationdate>20230602</creationdate><title>Application of oncolytic adenovirus expressing bispecific antibody in combination with CART in tumor treatment</title><author>WU HUAN ; WANG QIUMAN ; KONG BEIHUA ; YAN SHI ; SONG KUN ; LI RONGRONG ; YUAN CUNZHONG ; ZHANG QING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116196402A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WU HUAN</creatorcontrib><creatorcontrib>WANG QIUMAN</creatorcontrib><creatorcontrib>KONG BEIHUA</creatorcontrib><creatorcontrib>YAN SHI</creatorcontrib><creatorcontrib>SONG KUN</creatorcontrib><creatorcontrib>LI RONGRONG</creatorcontrib><creatorcontrib>YUAN CUNZHONG</creatorcontrib><creatorcontrib>ZHANG QING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WU HUAN</au><au>WANG QIUMAN</au><au>KONG BEIHUA</au><au>YAN SHI</au><au>SONG KUN</au><au>LI RONGRONG</au><au>YUAN CUNZHONG</au><au>ZHANG QING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of oncolytic adenovirus expressing bispecific antibody in combination with CART in tumor treatment</title><date>2023-06-02</date><risdate>2023</risdate><abstract>The invention belongs to the technical field of biological medicines, and particularly relates to application of oncolytic adenovirus expressing a bispecific antibody in combination with CART in tumor treatment. The invention provides combined application of three tumor immunotherapies of oncolytic adenovirus, a bispecific antibody and CART (chimeric antigen receptor T). The recombinant oncolytic adenovirus expresses and secretes MUC16-BiTE, and the MUC16-BiTE can bridge tumor cells and CART cells, induce immune synapse formation and stimulate CART cell activation; the recombinant oncolytic adenovirus can dissolve tumor cells, increase CART cell infiltration, generate a pro-inflammatory environment, promote solid tumor immune activation and overcome tumor immunosuppression. The MUC16-BiTE obtained after recombination can target a CART cell CD3 antigen and a tumor cell MUC16 antigen at the same time, the targeting performance of the CART is enhanced, meanwhile, adverse reactions caused by systemic administrati</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN116196402A |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Application of oncolytic adenovirus expressing bispecific antibody in combination with CART in tumor treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T20%3A33%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=WU%20HUAN&rft.date=2023-06-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN116196402A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |