Preparation method of begonin monomethyl ether

The invention discloses a method for preparing begonin monomethyl ether. In the application, the method comprises the following step: in an organic medium, carrying out a coupling reaction on a compound as shown in a formula VII and (tri-n-butyltin) methanol to obtain the begonin methyl ether. According to the preparation method of the begonin monomethyl ether provided by the invention, the use of a dimethyl methylene ylide active intermediate with a short half-life period is avoided, an amplification effect is avoided, and the yield is improved; the use of sulfur-containing materials is avoided, and the industrial prospect is very high. 本申请公开了一种制备山海棠素甲醚的方法。本申请中，所述方法包括步骤：在有机介质中，使式VII化合物和(三正丁基锡)甲醇发生偶联反应，得到山海棠素甲醚。本申请提供的山海棠素甲醚的制备方法，避免使用半衰期短的二甲基亚甲基鋶叶立德活性中间体，无放大效应，提高了收率；规避了含硫物料的使用，具备很高的工业化前景。