Compositions comprising amphiregulin-specific double-stranded oligonucleotide structures for prevention or treatment of obesity-related diseases

Compositions comprising amphiregulin-specific double-stranded oligonucleotide structures for prevention or treatment of obesity-related diseases

The present invention relates to: a double-stranded oligonucleotide which can highly specifically and effectively inhibit the expression of a bimodulin, preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA heterozygote; and the use of a double...

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Bibliographische Detailangaben
Hauptverfasser: SONG JIANG, PARK HAN-OH, LEE MI-SUN, PARK JUNE-HONG, HWANG SOO-HYUN, KIM JANG-SUN, CHOI SOON-JA, YOON SUNG-IL, KIM TAE-RIM, JUNG SANG-HYUK, SON SEUNG-SUB
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to: a double-stranded oligonucleotide which can highly specifically and effectively inhibit the expression of a bimodulin, preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA heterozygote; and the use of a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide for preventing or treating obesity. 本发明涉及：可以高度特异性地且有效地抑制双调蛋白表达的双链寡核苷酸，优选包含RNA/RNA、DNA/DNA或DNA/RNA杂合体形式的序列的双链寡核苷酸；以及包含所述双链寡核苷酸的双链寡核苷酸结构和纳米颗粒用于预防或治疗肥胖症的用途。