Anti-CLDN18.2 monoclonal antibody and application thereof

The invention provides an anti-CLDN18.2 monoclonal antibody and a preparation of the anti-CLDN18.2 monoclonal antibody. In particular, the invention provides a novel humanized antibody for resisting CLDN18.2. The invention also provides a preparation method of the humanized antibody for resisting CL...

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Bibliographische Detailangaben
Hauptverfasser:	QIU JIANHUA, QU AIDONG, LIANG HONGYUAN, ZHU JINGYE, WU LINA, ZHANG KUNMING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides an anti-CLDN18.2 monoclonal antibody and a preparation of the anti-CLDN18.2 monoclonal antibody. In particular, the invention provides a novel humanized antibody for resisting CLDN18.2. The invention also provides a preparation method of the humanized antibody for resisting CLDN18.2. The antibody provided by the invention can be combined with antigens with high specificity, has high affinity and high biological activity, can be specifically combined with human CLDN18.2 antigen molecules, and can efficiently inhibit tumors in vitro and in vivo. 本发明提供了抗CLDN18.2单克隆抗体及其制剂。具体地，本发明提供了一种新的抗CLDN18.2人源化抗体。本发明的抗体能够高特异性地结合抗原，具有高亲和力和高生物活性，可特异性结合人CLDN18.2抗原分子，在体外和体内均可高效地抑制肿瘤。