Antigen vector strain and application thereof in preparation of staphylococcus aureus oral vaccine
The invention discloses an antigen vector strain, a recombinant strain and application of the antigen vector strain in preparation of staphylococcus aureus oral vaccines, the strain is LR076 and is preserved in China General Microbiological Culture Collection Center on September 27, 2022, the preser...
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| creator | DU RUIPING WANG XIAO BAO XUEMEI |
| description | The invention discloses an antigen vector strain, a recombinant strain and application of the antigen vector strain in preparation of staphylococcus aureus oral vaccines, the strain is LR076 and is preserved in China General Microbiological Culture Collection Center on September 27, 2022, the preservation number is CGMCC No.25845, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the classification name is Limosilicilla reuteri; the recombinant strain is formed by transforming a recombinant plasmid carrying an exogenous staphylococcus aureus antigen fragment into an LR076 strain; the antigen fragments comprise HlaH35L, IsdB and MntC, and the HlaH35L, the IsdB and the MntC are respectively shown as SEQ ID NO. 1 to SEQ ID NO. 3. When the recombinant strain is applied to preparation of a staphylococcus aureus oral vaccine, pathological changes of infected lungs can be effectively relieved, and the fixed value amount of staphylococcus aureus in the lungs can be reduced. |
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When the recombinant strain is applied to preparation of a staphylococcus aureus oral vaccine, pathological changes of infected lungs can be effectively relieved, and the fixed value amount of staphylococcus aureus in the lungs can be reduced.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Antigen vector strain and application thereof in preparation of staphylococcus aureus oral vaccine |
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