Preparation and application of novel enamine sulfonyl fluoride compound with anti-tumor effect

The invention discloses a 2-chloro-2-vinyl-1-sulfonyl fluoride, an enamine sulfonyl fluoride compound and a preparation method of the 2-chloro-2-vinyl-1-sulfonyl fluoride and the enamine sulfonyl fluoride compound. Comprising the following steps: mixing 2-chloro-2-vinyl-1-sulfonyl fluoride serving a...

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Hauptverfasser: QIN HUALI, CHEN LIUYANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a 2-chloro-2-vinyl-1-sulfonyl fluoride, an enamine sulfonyl fluoride compound and a preparation method of the 2-chloro-2-vinyl-1-sulfonyl fluoride and the enamine sulfonyl fluoride compound. Comprising the following steps: mixing 2-chloro-2-vinyl-1-sulfonyl fluoride serving as a raw material with substituted aromatic amine containing different functional groups and aliphatic amine, adding alkali and a solvent, reacting at room temperature for 1-12 hours, and separating and purifying to obtain a series of novel enamine sulfonyl fluoride compounds. The enamine sulfonyl fluoride compound prepared by the method is obtained by removing one molecule of hydrogen chloride through simple addition and elimination reactions under the action of auxiliary alkali. A large number of literatures and researches show that many enamine-containing structures or sulfonyl fluoride groups have various biological activities, and the product simultaneously contains the enamine structures and the sulfonyl fluor