Preparation method of oxolinic acid intermediate

The invention discloses a preparation method of an oxolinic acid intermediate, which comprises the following steps: adding water, pepper amine and acrylic ester into a microwave tube, carrying out microwave heating to generate N-propionate pepper amine, then adding sodium hydroxide or potassium hydroxide, and carrying out microwave heating; and cooling the product to 5-20 DEG C, standing, and carrying out oil-water separation to obtain an oily substance which is the target product. The method has the advantages of easily available raw materials, mild reaction conditions, environmental protection, safety, simplicity, high efficiency, simplicity and convenience in operation, high automation degree and suitability for industrial production by using water as a solvent. 本发明公开了一种噁喹酸中间体的制备方法，所述方法为在微波管中加入水、胡椒胺和丙烯酸酯，微波加热，生成N-丙酸酯胡椒胺，然后加入氢氧化钠或氢氧化钾，再微波加热；产物冷却到5-20℃，静置，油水分离，油状物即为目标产物。该方法原料易得、反应条件温和、以水做溶剂绿色环保、安全、简单高效、操作简便，自动化程度高，适于工业化生产。